Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. - Wikidata - wikimedia - TriplyDB

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

http://www.wikidata.org/entity/Q36720582

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Potential Modulation of Sirtuins by Oxidative Stress Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in β Cell Function and Dysfunction At the interface of antioxidant signalling and cellular function: Key polyphenol effects Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds Recent progress in metabolic signaling pathways regulating aging and life span It takes two to tango: NAD+ and sirtuins in aging/longevity control NAD+ and sirtuins in aging and disease.Suppression of silent information regulator 1 activity in noncancerous tissues of hepatocellular carcinoma: Possible association with non-B non-C hepatitis pathogenesis.Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility.Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference.NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus Systemic regulation of mammalian ageing and longevity by brain sirtuins.Interventions to Slow Aging in Humans: Are We Ready?Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats Apigenin Ameliorates Dyslipidemia, Hepatic Steatosis and Insulin Resistance by Modulating Metabolic and Transcriptional Profiles in the Liver of High-Fat Diet-Induced Obese Mice.CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.Sirtuin activation as a therapeutic approach against inborn errors of metabolism.Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing.Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1.Accurate measurement of nicotinamide adenine dinucleotide (NAD⁺) with high-performance liquid chromatography.Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.Differential impact of flavonoids on redox modulation, bioenergetics and cell signalling in normal and tumor cells: a comprehensive review.Protein acetylation in metabolism - metabolites and cofactors.Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration.Apigenin alleviates STZ-induced diabetic cardiomyopathy.The antiproliferative and apoptotic effects of apigenin on glioblastoma cells.Sirtuins, a promising target in slowing down the ageing process.Pharmacokinetic properties and drug interactions of apigenin, a natural flavone.NAD and the aging process: Role in life, death and everything in between.CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets.Effect of bafilomycin and NAADP on membrane-associated ATPases and respiration of isolated mitochondria of the murine Nemeth-Kellner lymphoma.NAD(+) : a key metabolic regulator with great therapeutic potential.A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver Why NAD(+) Declines during Aging: It's Destroyed.Apigenin and quercetin ameliorate mitochondrial alterations by tunicamycin-induced ER stress in 3T3-L1 adipocytes.CD38 modulates respiratory syncytial virus-driven pro-inflammatory processes in human monocyte-derived dendritic cells.Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences.Apigenin Ameliorates the Obesity-Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of Obese Mice.Quercetin Improves Glucose and Lipid Metabolism of Diabetic Rats: Involvement of Akt Signaling and SIRT1.

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Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

http://www.wikidata.org/entity/Q36720582

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Flavonoid apigenin is an inhib ...... eatment of metabolic syndrome.

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Flavonoid apigenin is an inhib ...... eatment of metabolic syndrome.

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Ana P Gomes

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Carlos Escande

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Eduardo N Chini

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Luke O'Neil

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Maria Thereza Barbosa

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Nathan L Price

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Thomas A White

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Verena Capellini

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Veronica Nin

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P2860

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.

Global nutrition transition and the pandemic of obesity in developing countries

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Resveratrol improves health and survival of mice on a high-calorie diet

Dietary flavonoids: bioavailability, metabolic effects, and safety

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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1084-1093

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10.2337/DB12-1139

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62

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metabolic syndrome

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