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Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsMulti-Facial, Non-Peptidic α-Helix MimeticsDiscovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography †Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainEnhancement of α-Helix Mimicry by an α/β-Peptide Foldamer via Incorporation of a Dense Ionic Side-Chain ArrayExploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein–protein interaction in C. hominis thymidylate synthase-dihydrofolate reductase (TS-DHFR)A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitinsA spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell cultureConformationally rigid proteomimetics: a case study in designing antimicrobial aryl oligomers.Expanding the scope of oligo-pyrrolinone-pyrrolidines as protein-protein interface mimics.Heterocyclic alpha-helix mimetics for targeting protein-protein interactionsContemporary strategies for the stabilization of peptides in the alpha-helical conformation.Electrostatic contacts in the activator protein-1 coiled coil enhance stability predominantly by decreasing the unfolding rate.Reversible and noncompetitive inhibition of beta-tryptase by protein surface binding of tetravalent peptide ligands identified from a combinatorial split-mix library.Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potencyNovel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsUniversal peptidomimetics.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation.Minimalist and universal peptidomimetics.Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone.Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.Oxetanyl peptides: novel peptidomimetic modules for medicinal chemistry.A biomimetic polyketide-inspired approach to small-molecule ligand discovery.A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.Pyrrole-based scaffolds for turn mimics.Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.Pyrrolinone-pyrrolidine oligomers as universal peptidomimeticsSynthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.Synthetic mimetics of protein secondary structure domainsState-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.GLUE that sticks to HIV: a helix-grafted GLUE protein that selectively binds the HIV gp41 N-terminal helical region.Probing Protein Surfaces: QSAR Analysis with Helix Mimetics.Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold.End-Capped α-Helices as Modulators of Protein FunctionAssessment of helical interfaces in protein-protein interactionsAn α-helical peptidomimetic scaffold for dynamic combinatorial library formation.Preparation of diazabicyclo[4.3.0]nonene-based peptidomimeticsSynthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Synthetic non-peptide mimetics of alpha-helices.
@ast
Synthetic non-peptide mimetics of alpha-helices.
@en
type
label
Synthetic non-peptide mimetics of alpha-helices.
@ast
Synthetic non-peptide mimetics of alpha-helices.
@en
prefLabel
Synthetic non-peptide mimetics of alpha-helices.
@ast
Synthetic non-peptide mimetics of alpha-helices.
@en
P2093
P2860
P356
P1476
Synthetic non-peptide mimetics of alpha-helices.
@en
P2093
Andrew D Hamilton
Jessica M Davis
Lun K Tsou
P2860
P304
P356
10.1039/B608043J
P577
2007-01-04T00:00:00Z