Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. - Wikidata - wikimedia - TriplyDB

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

http://www.wikidata.org/entity/Q36735157

about

Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Plasminogen Activator Inhibitor-1 in Cancer: Rationale and Insight for Future Therapeutic Testing Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity.Targeting Abeta and tau in Alzheimer's disease, an early interim report Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons.Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population.PAI-1 antagonists: the promise and the peril.Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals.Drug development for Alzheimer's disease: recent progress Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity.Transcriptomics Profiling of Alzheimer's Disease Reveal Neurovascular Defects, Altered Amyloid-β Homeostasis, and Deregulated Expression of Long Noncoding RNAs Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease.Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease.Evoking plasmin for beta-amyloid clearance.The AbetaCs of Abeta-cleaving proteases.Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta.Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression.Physiological responses to protein aggregates: fibrinolysis, coagulation and inflammation (new roles for old factors).uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin.Computational insights into the development of novel therapeutic strategies for Alzheimer's disease.Tissue-type plasminogen activator-mediated plasminogen activation and contact activation, implications in and beyond haemostasis.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?Proteolytic degradation of amyloid β-protein.Beta-amyloidolysis and glutathione in Alzheimer's disease.Modulating nitric oxide signaling in the CNS for Alzheimer's disease therapy.Aβ-Degrading Proteases: Therapeutic Potential in Alzheimer Disease.Progress in the development of new drugs in Alzheimer's disease.Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease.Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons.Novel Combinatorial Therapeutic Targeting of PAI-1 (SERPINE1) Gene Expression in Alzheimer's Disease Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.Activators and inhibitors of the plasminogen system in Alzheimer's disease.Tissue-type plasminogen activator binds to Aβ and AIAPP amyloid fibrils with multiple domains.Valproic acid-mediated inhibition of trimethyltin-induced deficits in memory and learning in the rat does not directly depend on its anti-oxidant properties.Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.

P2860

Q21202832-A7FBDA8C-5255-4B1B-B8BD-0FE5ACE2B165 Q26801060-096C011C-D5C2-4BFD-8867-9EEFCEC6A2AC Q27005843-12FA7D3E-2C5E-4AA8-A1A0-C1D4A56F88FB Q28475342-547DCF0E-B6E8-4967-A164-3CF8C134C8C5 Q33536103-5A36102F-40B9-4123-ABDC-71F580EA1CCC Q33829008-85714A4B-F37C-480B-9284-9CBCEADBD9F6 Q33895062-AE001EC9-9CBE-408C-96EF-B9A4BC43E551 Q33925397-349B49A7-F9EB-4BA0-8D96-3A4ED3FF1E02 Q34049978-D9601992-6B0A-46F3-988D-5D0AC9797119 Q34110227-F919B0FE-0915-4B95-A511-A365DAB29BAF Q34720291-FB5F2A57-DE1C-4508-92D0-4C14CF72DAD8 Q35048985-6767D991-6351-4390-8988-100F2B601000 Q35076119-5F7F4E6A-D910-495E-990E-FD40706D1A3D Q35545974-ABD02452-5B49-4732-AD27-50941CCEEE56 Q36162638-CBAE4DC5-0D45-48C6-9EFB-D4540378F9DA Q36421684-32AF7720-58F3-4430-BF17-555DD4E4A4C6 Q36940911-8EB2DCAE-55D7-475D-8AB5-0EA8C9D35A09 Q37224550-F23240E9-24A3-432D-9092-AB0841DA0E30 Q37234992-819FC4B2-E291-4909-9ED8-63D77280B9B5 Q37250796-FC08327F-4768-4EE4-9046-0A384291490C Q37257169-F6B8998B-F003-4B5F-B4B2-ACEAC7F36890 Q37516148-913DE86E-E79F-4911-8784-06BFC497C88B Q37520011-F165440F-C49A-41AB-B57A-F502964C6F2A Q37629834-11146415-2F1E-4219-8645-4224D8C183E9 Q37855869-5D68355F-0943-4CCA-A7FD-AAB01429AC52 Q37903940-10981F73-B93C-43E2-B64F-B4364A920C1A Q37961852-FB34CDA1-7506-4A5A-9D65-97975303DA8E Q38016899-10DEA5CC-6EA8-4166-AFB4-0C3AF24BCD11 Q38104717-A70FDD55-1415-474D-AEDA-DA20C5191748 Q38126948-B01D6333-7279-40BE-BCB9-E529F15EE451 Q38878922-01A868E4-9093-4B31-80D2-75483F3CE5AF Q39789745-5C95FCA7-1C3A-423C-B4A1-737C73EE9A10 Q39908636-94D9625E-1ED1-467B-9FCE-69870BD42C3A Q40532626-AE30E7EF-D00C-4278-976A-FED3BEE84FD4 Q41842704-13AB66BC-2A0B-4E62-9106-93849565A486 Q42364420-7089CB88-DBFA-44A7-A8F1-A4483D272744 Q42914615-F8F87D02-3C48-42FF-8C6A-D1DC313A4186 Q44528080-3756978F-EABD-48A6-BA87-7D84D0B848A2 Q48351124-5185CB4F-2180-42C0-9941-1908E0DE4044 Q50706209-4ABE553A-AD1D-4213-B159-DD9F44B56CFD

P2860

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

http://www.wikidata.org/entity/Q36735157

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@ast

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@en

type

label

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@ast

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@en

prefLabel

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@ast

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@en

P1433

Q36735157-07426B72-B6D9-4922-9097-C19E6FCAC6C1

P1476

Q36735157-C4E41196-EAE4-4979-8E19-05C7122A1D1F

P2093

Q36735157-02830721-6F06-4248-9EE9-247AE8736A9A

Q36735157-0DC6665E-962B-45D8-A845-E9DF75669634

Q36735157-17702265-E7DE-4693-9675-D8F1A4C30FAA

Q36735157-258B3068-BAA4-4CB3-AB82-D168C84C03F6

Q36735157-407F7073-B6E5-4560-9566-04C0D3BDB490

Q36735157-40D60335-9129-4899-8B8B-6064215A3EF1

Q36735157-4774EF9A-8425-4100-AFC3-1F84517B9C4B

Q36735157-507CD508-E922-4304-A57B-1E330571B0AB

Q36735157-5B33A7FD-EE1C-4F61-833B-8CDA82D6BBEF

Q36735157-65728B94-49EC-427C-98E9-9F144A300080

P2860

Q36735157-00D33C05-0EF1-4781-8AA4-E9D6739B355F

Q36735157-0365264D-A7FD-421F-94CC-A6E1D81212E1

Q36735157-05D055C6-42AC-4208-BED2-EC1F2A6A14B4

Q36735157-0D527977-BE81-44F4-9089-93C226EC65FA

Q36735157-17FE6825-8937-4F04-895A-B4C6A73A23D2

Q36735157-1C7ACEBF-E4D5-4631-B80A-BE2144DEB348

Q36735157-2BCDDD48-387F-4ACC-A310-FFC729E00591

Q36735157-2CD3D889-8D34-4310-A564-9EB3F9E49656

Q36735157-31F41EE3-2228-47BB-A326-624F9A68A76D

Q36735157-49671197-13E7-405B-8F41-C504A4818B44

P304

Q36735157-06211B29-0FB8-4483-98F4-556C32CCF989

P31

Q36735157-D574B298-770E-473B-BF90-AE16F55B7CD1

P356

Q36735157-0DB47922-72F8-4D87-99D1-23FBFF0CB334

P407

Q36735157-46EE754A-20E5-4FB4-97F9-4EDBA383B891

P433

Q36735157-8A2B0783-38C5-4BCB-92DF-BD4BD2C8250B

P478

Q36735157-489BA52F-CF01-47E1-AB6D-F4245D2B9FA9

P577

Q36735157-84E302CD-D7C8-488A-BB46-D0368504029A

P5875

Q36735157-D7ABF43D-0115-4971-97D9-AA7E2DF8F139

P698

Q36735157-FB5227EA-C982-405A-95FB-583FBA2C15F3

P921

Q36735157-DED91738-5A50-480F-A33C-66C38A2311E4

P932

Q36735157-658702BE-265B-4DA0-B133-AE6ED4E9C426

P356

PNAS.0710823105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade.

@en

P2093

Albert Robichaud

http://www.w3.org/2001/XMLSchema#string

Aram Oganesian

http://www.w3.org/2001/XMLSchema#string

Cathleen Gonzales

http://www.w3.org/2001/XMLSchema#string

David L Crandall

http://www.w3.org/2001/XMLSchema#string

David Riddell

http://www.w3.org/2001/XMLSchema#string

Erik Wagner

http://www.w3.org/2001/XMLSchema#string

George P Vlasuk

http://www.w3.org/2001/XMLSchema#string

Hassan Elokdah

http://www.w3.org/2001/XMLSchema#string

Hua Zhou

http://www.w3.org/2001/XMLSchema#string

Indranil Das

http://www.w3.org/2001/XMLSchema#string

P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

Alzheimer's disease: genes, proteins, and therapy

Proteolysis in Alzheimer's disease. Can plasmin tip the balance?

Clearing the brain's amyloid cobwebs.

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

Extracellular proteolysis in the adult murine brain

Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease.

Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus.

P304

8754-8759

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0710823105

http://www.w3.org/2001/XMLSchema#string

P407

P433

25

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P577

2008-06-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5296579

http://www.w3.org/2001/XMLSchema#string

P698

18559859

http://www.w3.org/2001/XMLSchema#string

P921

P932

2438386

http://www.w3.org/2001/XMLSchema#string