IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. - Wikidata - wikimedia - TriplyDB

IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.

IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.

http://www.wikidata.org/entity/Q36745302

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Follicular helper T cells in immunity and systemic autoimmunity Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis.Dysregulated CD4+ T cells from SLE-susceptible mice are sufficient to accelerate atherosclerosis in LDLr-/- mice.Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1+CXCR5-/dim B-helper T cell induction Altered B cell signalling in autoimmunity.Prevention of immune nephritis by the small molecular weight immunomodulator iguratimod in MRL/lpr mice.Beyond regulatory T cells: the potential role for IL-2 to deplete T-follicular helper cells and treat autoimmune diseases.Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R⁺ T cells.Development of Th17-Associated Interstitial Kidney Inflammation in Lupus-Prone Mice Lacking the Gene Encoding STAT-1.IFN-γ receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity.Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation.STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus.IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.The cellular source and target of IL-21 in K/BxN autoimmune arthritis Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.Cytokine-Mediated Regulation of Plasma Cell Generation: IL-21 Takes Center Stage.Ly108 expression distinguishes subsets of invariant NKT cells that help autoantibody production and secrete IL-21 from those that secrete IL-17 in lupus prone NZB/W mice.T cells that promote B-Cell maturation in systemic autoimmunity The darker side of follicular helper T cells: from autoimmunity to immunodeficiency.Follicular helper T cells: new insights into mechanisms of autoimmune diseases.Interleukin-21 in chronic inflammatory diseases.Aberrant B cell selection and activation in systemic lupus erythematosus.The unique features of follicular T cell subsets.Autoimmunity in 2012.Contributions of B cells to lupus pathogenesis IL-21 as a therapeutic target in inflammatory disorders.T follicular helper cells, interleukin-21 and systemic lupus erythematosus.Spontaneous germinal centers and autoimmunity.T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses?Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients.Interleukin-21 receptor blockade inhibits secondary humoral responses and halts the progression of preestablished disease in the (NZB × NZW)F1 systemic lupus erythematosus model.Interleukin-21, a potential diagnostic and therapeutic target for systemic lupus erythematosus.Human Umbilical Cord Mesenchymal Stem Cells Inhibit T Follicular Helper Cell Expansion Through the Activation of iNOS in Lupus-Prone B6.MRL-Faslpr Mice.Anti-IL21 receptor monoclonal antibody (ATR-107): Safety, pharmacokinetics, and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study.CTL-Promoting Effects of IL-21 Counteract Murine Lupus in the Parent→F1 Graft-versus-Host Disease Model.

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IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.

http://www.wikidata.org/entity/Q36745302

description

2012 nî lūn-bûn

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IL-21 receptor is required for ...... n MRL/MpJ-Fas(lpr/lpr)/J mice.

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IL-21 receptor is required for ...... n MRL/MpJ-Fas(lpr/lpr)/J mice.

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IL-21 receptor is required for ...... n MRL/MpJ-Fas(lpr/lpr)/J mice.

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IL-21 receptor is required for ...... n MRL/MpJ-Fas(lpr/lpr)/J mice.

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IL-21 receptor is required for ...... n MRL/MpJ-Fas(lpr/lpr)/J mice.

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JIMMUNOL.1003871

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Journal of Immunology

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Andrew L Rankin

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Cheryl Nickerson-Nutter

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Deborah Herber

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Deborah Young

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Heath Guay

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Joe Craft

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Kyri Dunussi-Joannopoulos

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Mark Ryan

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Mary Collins

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P2860

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

Interleukin-21 inhibits dendritic cell activation and maturation

Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

A critical role for IL-21 in regulating immunoglobulin production

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

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1656-1667

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10.4049/JIMMUNOL.1003871

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188

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3618484

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