Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin
about
Heterotrimeric G proteins as emerging targets for network based therapy in cancer: End of a long futile campaign striking heads of a HydraGIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin.Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors.Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomySubstrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency.Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity.Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin and G proteins.GIV/Girdin activates Gαi and inhibits Gαs via the same motifThe untapped potential of tyrosine-based G protein signaling.Heterotrimeric G protein signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles.A chimeric antibody targeting CD147 inhibits hepatocellular carcinoma cell motility via FAK-PI3K-Akt-Girdin signaling pathway.GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis.Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block.G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron.Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells.Clinical implications of Girdin protein expression in glioma.
P2860
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P2860
Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Protein kinase C-theta (PKCθ) ...... ne exchange factor, GIV/Girdin
@en
type
label
Protein kinase C-theta (PKCθ) ...... ne exchange factor, GIV/Girdin
@en
prefLabel
Protein kinase C-theta (PKCθ) ...... ne exchange factor, GIV/Girdin
@en
P2093
P2860
P921
P356
P1476
Protein kinase C-theta (PKCθ) ...... ne exchange factor, GIV/Girdin
@en
P2093
Inmaculada López-Sánchez
Marilyn G Farquhar
Pradipta Ghosh
Yash Mittal
P2860
P304
P356
10.1073/PNAS.1303392110
P407
P577
2013-03-18T00:00:00Z