Rational reprogramming of fungal polyketide first-ring cyclization - Wikidata - wikimedia - TriplyDB

Rational reprogramming of fungal polyketide first-ring cyclization

Rational reprogramming of fungal polyketide first-ring cyclization

http://www.wikidata.org/entity/Q36747665

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Recent advances in genome mining of secondary metabolites in Aspergillus terreus Insights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae.Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases.Fungal polyketide engineering comes of age.Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis.Three new resorcylic acid derivatives from Sporotrichum laxum Diversity-Oriented Combinatorial Biosynthesis of Hybrid Polyketide Scaffolds from Azaphilone and Benzenediol Lactone Biosynthons.Explorations of fungal biosynthesis of reduced polyketides - a personal viewpoint.Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases.Examination of Potential Exceptions to the F and S Biosynthetic Classification of Fused-Ring Aromatic Polyketides.Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs Identification of a type III polyketide synthase involved in the biosynthesis of spirolaxine.Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase.Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases.

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Rational reprogramming of fungal polyketide first-ring cyclization

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Rational reprogramming of fungal polyketide first-ring cyclization

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Rational reprogramming of fungal polyketide first-ring cyclization

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Rational reprogramming of fungal polyketide first-ring cyclization

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PNAS.1301201110

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Proceedings of the National Academy of Sciences of the United States of America

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Rational reprogramming of fungal polyketide first-ring cyclization

@en

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Jia Zeng

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Jixun Zhan

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Min Lin

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Ming Chen

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Shiyou Su

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Sue A Roberts

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Tong Zhou

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Wei Zhang

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William R Montfort

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Yuquan Xu

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P2860

Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

Structural and Biochemical Characterization of ZhuI Aromatase/Cyclase from the R1128 Polyketide Pathway

Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI

Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus

Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii

Chemistry and biology of resorcylic acid lactones

3D-Jury: a simple approach to improve protein structure predictions

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