Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
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An in vitro polysome display system for identifying ligands from very large peptide librariesLC/MS applications in drug developmentLigands for kappa-opioid and ORL1 receptors identified from a conformationally constrained peptide combinatorial libraryProtein molecular surface mapped at different geometrical resolutionsThe universal statistical distributions of the affinity, equilibrium constants, kinetics and specificity in biomolecular recognitionChemical ecology: a view from the pharmaceutical industryCombinatorial approaches to harmacophoric heterocycles: A solid-phase synthesis of 3,1-benzoxazine-4-onesGeneration of a library of 4-thiazolidinones utilizing polymer supported quench (PSQ) reagent methodologyA convenient method for library construction: parallel synthesis of beta-amino ester and quinoline derivatives in liquid phase using Ln(OTf)3-catalyzed three-component reactionsTwo-dimensional parallel array technology as a new approach to automated combinatorial solid-phase organic synthesisMonitoring solution-phase combinatorial library synthesis by capillary electrophoresis.A strategy for the generation of biomimetic ligands for affinity chromatography. Combinatorial synthesis and biological evaluation of an IgG binding ligand.Optimization of solid supports for combinatorial chemical synthesis.Production of cyclic peptides and proteins in vivoSystematic study of the substituted active C-terminus of hirudin.Predictive Array Design. A method for sampling combinatorial chemistry library space.Screening of ligand binding on melatonin receptor using non-peptide combinatorial libraries.The BAD project: data mining, database and prediction of protein adsorption on surfaces.Applications of display technology in protein analysis.Design, docking, and evaluation of multiple libraries against multiple targets.Sample size determination in combinatorial chemistryDendrimer-supported combinatorial chemistry.Recursive Partitioning analysis of mu-opiate receptor high throughput screening results.High-throughput screening and quantitative structure-efficacy relationship models of potential displacer molecules for ion-exchange systems.Emerging techniques for the discovery and validation of therapeutic targets for skeletal diseases.Coloured peptides: synthesis, properties and use in preparation of peptide sub-library kits.Allosteric activation of the follicle-stimulating hormone (FSH) receptor by selective, nonpeptide agonists.Use of ionically tagged glycosyl donors in the synthesis of oligosaccharide libraries.Biodegradable fibrous scaffolds with diverse properties by electrospinning candidates from a combinatorial macromer library.Solid-supported reagents in organic synthesis.Screening for novel antimicrobials from encoded combinatorial libraries by using a two-dimensional agar format.Characterization of oligodeoxyribonucleotide synthesis on glass plates.Screening and rank ordering of reversible mechanism-based inhibitors of hepatitis C virus NS3 protease using electrospray ionization mass spectrometry.Superaugmented eccentric distance sum connectivity indices: novel highly discriminating topological descriptors for QSAR/QSPR.Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analysesMarine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactivesImmunoglobulin purification by affinity chromatography using protein A mimetic ligands prepared by combinatorial chemical synthesis.Downhill kinetics of biomolecular interface binding: globally connected scenarioLibrary of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.Protein-peptide interactions analyzed with the yeast two-hybrid system.
P2860
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P2860
Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Applications of combinatorial ...... tegies, and future directions.
@en
type
label
Applications of combinatorial ...... tegies, and future directions.
@en
prefLabel
Applications of combinatorial ...... tegies, and future directions.
@en
P2093
P356
P1476
Applications of combinatorial ...... tegies, and future directions.
@en
P2093
P304
P356
10.1021/JM00036A001
P407
P577
1994-05-01T00:00:00Z