From magic bullets back to the magic mountain: the rise of extensively drug-resistant tuberculosis.
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Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and ImprovementThiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteriaDrug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosisHigh-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosisRapid diagnosis of drug resistance to fluoroquinolones, amikacin, capreomycin, kanamycin and ethambutol using genotype MTBDRsl assay: a meta-analysisPreliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) from Mycobacterium tuberculosisFunctional characterization by genetic complementation of aroB-encoded dehydroquinate synthase from Mycobacterium tuberculosis H37Rv and its heterologous expression and purificationRv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphataseElucidating emergence and transmission of multidrug-resistant tuberculosis in treatment experienced patients by whole genome sequencingAntibiotics for emerging pathogensThe future of molecular diagnostics for drug-resistant tuberculosis.The conserved Lysine69 residue plays a catalytic role in Mycobacterium tuberculosis shikimate dehydrogenase.Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle.Validation of the GenoType MTBDRplus assay for detection of MDR-TB in a public health laboratory in Thailand.Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters.Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice.Tuberculosis in Sudan: a study of Mycobacterium tuberculosis strain genotype and susceptibility to anti-tuberculosis drugs.Analysis of gene mutations associated with isoniazid, rifampicin and ethambutol resistance among Mycobacterium tuberculosis isolates from EthiopiaAntibiotics and bacterial resistance in the 21st century.Extensively Drug-Resistant Tuberculosis: A Sign of the Times and an Impetus for Antimicrobial Discovery.Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosisAddressing institutional amplifiers in the dynamics and control of tuberculosis epidemics.Design, synthesis, and study of a mycobactin-artemisinin conjugate that has selective and potent activity against tuberculosis and malariaMolecular epidemiology and transmission dynamics of Mycobacterium tuberculosis in Northwest Ethiopia: new phylogenetic lineages found in Northwest Ethiopia.Hydrogels and scaffolds for immunomodulationIsoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin NLaboratory diagnosis of tuberculosis in resource-poor countries: challenges and opportunitiesEpidemiology and Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa.Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosisEpidemiology and challenges to the elimination of global tuberculosis.Pyrido[1,2-a]benzimidazole-based agents active against tuberculosis (TB), multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TBMolecular Imaging of Growth, Metabolism, and Antibiotic Inhibition in Bacterial Colonies by Laser Ablation Electrospray Ionization Mass Spectrometry.Tuberculosis and its future management.Genetic determinants of drug-resistant tuberculosis among HIV-infected patients in NigeriaBlockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.Mutation adjacent to the active site tyrosine can enhance DNA cleavage and cell killing by the TOPRIM Gly to Ser mutant of bacterial topoisomerase I.Structural basis of rifampin inactivation by rifampin phosphotransferase.Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region.
P2860
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P2860
From magic bullets back to the magic mountain: the rise of extensively drug-resistant tuberculosis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
From magic bullets back to the ...... y drug-resistant tuberculosis.
@en
type
label
From magic bullets back to the ...... y drug-resistant tuberculosis.
@en
prefLabel
From magic bullets back to the ...... y drug-resistant tuberculosis.
@en
P356
P1433
P1476
From magic bullets back to the ...... y drug-resistant tuberculosis.
@en
P2093
Susan E Dorman
P2888
P304
P356
10.1038/NM0307-295
P407
P577
2007-03-01T00:00:00Z