Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease
about
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Impaired TrkB Signaling Underlies Reduced BDNF-Mediated Trophic Support of Striatal Neurons in the R6/2 Mouse Model of Huntington's Disease.The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice.Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.
P2860
Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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name
Selective reduction of striata ...... model of Huntington's disease
@ast
Selective reduction of striata ...... model of Huntington's disease
@en
type
label
Selective reduction of striata ...... model of Huntington's disease
@ast
Selective reduction of striata ...... model of Huntington's disease
@en
prefLabel
Selective reduction of striata ...... model of Huntington's disease
@ast
Selective reduction of striata ...... model of Huntington's disease
@en
P2093
P2860
P1476
Selective reduction of striata ...... model of Huntington's disease
@en
P2093
Barbara L Hempstead
Jianmin Yang
Teresa A Milner
P2860
P304
P356
10.1016/J.NBD.2015.08.008
P577
2015-08-14T00:00:00Z