Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
about
Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53Uncovering the role of p53 splice variants in human malignancy: a clinical perspectiveSmall molecule compounds targeting the p53 pathway: are we finally making progress?Molecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaPrinciples of cancer therapy: oncogene and non-oncogene addictionThe senescence-associated secretory phenotype: the dark side of tumor suppressionPRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.Using high-throughput sequencing transcriptome data for INDEL detection: challenges for cancer drug discovery.Targeting p53 for Novel Anticancer Therapy.Senescent cells as a source of inflammatory factors for tumor progression.Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunitiesHigh glucose dephosphorylates serine 46 and inhibits p53 apoptotic activityp53 Family and Cellular Stress Responses in Cancer.Stage-specific sensitivity to p53 restoration during lung cancer progression.A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells.TP53 mutations in nonsmall cell lung cancerAd-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib.Structural effects of the L145Q, V157F, and R282W cancer-associated mutations in the p53 DNA-binding core domainProteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.Mechanism of initiation of aggregation of p53 revealed by Φ-value analysisTrans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo.Wild type p53 reactivation: from lab bench to clinic.TP53 transcription factor for the NEDD9/HEF1/Cas-L gene: potential targets in Non-Small Cell Lung Cancer treatment.Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides.Negative regulation-resistant p53 variant enhances oncolytic adenoviral gene therapy.RBBP6: a potential biomarker of apoptosis induction in human cervical cancer cell linesSelective requirement for Mediator MED23 in Ras-active lung cancer.Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer.An Amphiphilic Peptide Induces Apoptosis Through the miR29b-p53 Pathway in Cancer CellsZinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells.A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.Knitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy.Homeobox protein VentX induces p53-independent apoptosis in cancer cells.Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.Gentian violet induces wtp53 transactivation in cancer cellsSuppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo.Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumorsp53-targeted cancer pharmacotherapy: move towards small molecule compounds.RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response.Pharmacological reactivation of p53 as a strategy to treat cancer.
P2860
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P2860
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@ast
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@en
type
label
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@ast
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@en
prefLabel
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@ast
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@en
P2860
P356
P1433
P1476
Reactivation of mutant p53: molecular mechanisms and therapeutic potential.
@en
P2093
Selivanova G
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210295
P407
P577
2007-04-01T00:00:00Z
P5875
P6179
1024873323