Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase.
about
Multiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Replication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.HIV-1 RT-associated ribonuclease H displays both endonuclease and 3'----5' exonuclease activityThe nature of the N-terminal amino acid residue of HIV-1 RNase H is critical for the stability of reverse transcriptase in viral particles.Unusual features of the retroid element PAT from the nematode Panagrellus redivivusMutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.SiRNA-induced mutation in HIV-1 polypurine tract region and its influence on viral fitness.RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-templateMutations in the 5' end of the human immunodeficiency virus type 1 polypurine tract affect RNase H cleavage specificity and virus titer.An unusual mechanism of self-primed reverse transcription requires the RNase H domain of reverse transcriptase to cleave an RNA duplex.Human immunodeficiency viruses containing heterologous enhancer/promoters are replication competent and exhibit different lymphocyte tropisms.RNase H activity associated with reverse transcriptase from feline immunodeficiency virusReconstitution in vitro of RNase H activity by using purified N-terminal and C-terminal domains of human immunodeficiency virus type 1 reverse transcriptase.Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases HEffects of mutations in the G tract of the human immunodeficiency virus type 1 polypurine tract on virus replication and RNase H cleavageIsothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication.Sequence requirements for removal of tRNA by an isolated human immunodeficiency virus type 1 RNase H domainDefects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase H.Role of RNase H1 in DNA repair: removal of single ribonucleotide misincorporated into DNA in collaboration with RNase H2.Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptase.Two defective forms of reverse transcriptase can complement to restore retroviral infectivityInsights into the structure and activity of prototype foamy virus RNase H.Identification of a sequence element immediately upstream of the polypurine tract that is essential for replication of simian immunodeficiency virus.
P2860
Q33695787-2CEDED1E-A129-460E-9E5B-39D94A8D26B9Q33843501-F0EB94CE-90DD-429A-B34D-040B62A0374DQ34035941-4168735B-60D0-4B14-8D8A-FB94CE4CCE52Q34557590-A20D747F-10C5-4559-B20D-572D5C304EAFQ34991047-F66AA059-3047-4A25-A490-07FBFD3A5730Q35065933-BE54FDC8-5AE3-40A4-8DF4-F1AB6F1EDEAFQ35155286-F6233D52-4640-46B0-BA4A-07D1C906F21DQ35362902-E933059E-FEEF-417E-BEE8-6E4B8C22F85FQ36098739-825BC731-3E0C-4DAE-BDFC-0019ACFCACBCQ36474184-F697C00A-58ED-4027-8559-C9FBF885E6CCQ36562838-2D50B864-0397-4D38-86D4-9E8130B38ED1Q36640831-AB736518-6D51-43EC-BD31-3E3E4AE43034Q36690814-B232E3EA-2902-44B5-95B7-0EDB0DDB3CF6Q37396397-1D3E64E0-1487-4889-AE0A-73843C766D09Q37431890-D735BD1E-2786-4FC5-8B10-DB0004FCB0D6Q37596444-7412A14A-48A9-403B-BEF9-9DFC81C1492AQ37711871-B94CCF49-B8B2-4FA8-BDD3-69C5DF6614BEQ39579834-64F1E059-E44B-4315-8D3E-CE55218527C9Q40063803-3D8D7846-C786-488C-BB3A-A963154AD22AQ40395197-F820B4A7-127E-42D8-8131-FB7F6255A4D0Q40523947-6D678F82-FCEB-4DA6-98D2-2676441994D1Q40874391-31258302-0D03-4E4E-BD38-300EDF08915EQ41917489-8A41B508-939B-4AD4-9C21-D576F135A594Q42648096-E97A570D-40C6-452E-8840-BA444361D5A9
P2860
Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Inhibition of RNase H activity ...... a virus reverse transcriptase.
@en
type
label
Inhibition of RNase H activity ...... a virus reverse transcriptase.
@en
prefLabel
Inhibition of RNase H activity ...... a virus reverse transcriptase.
@en
P2093
P2860
P1433
P1476
Inhibition of RNase H activity ...... a virus reverse transcriptase.
@en
P2093
P2860
P304
P407
P577
1989-03-01T00:00:00Z