Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster
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Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in DrosophilaA motor function for the DEAD-box RNA helicase, Gemin3, in DrosophilaSolution structure of the core SMN–Gemin2 complexStructural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5Identification of gemin5 as a novel 7-methylguanosine cap-binding proteinThe SMN structure reveals its crucial role in snRNP assemblyCohesive versus flexible evolution of functional modules in eukaryotesEvolutionary flexibility of protein complexes.Enrichment of homologs in insignificant BLAST hits by co-complex network alignment.Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction.The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP AssemblyInvertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.The pre-mRNA splicing machinery of trypanosomes: complex or simplified?The Gemin associates of survival motor neuron are required for motor function in Drosophila.Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila.The spliceosome assembly factor GEMIN2 attenuates the effects of temperature on alternative splicing and circadian rhythms.Reconstitution of the human U snRNP assembly machinery reveals stepwise Sm protein organizationBehavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster.Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle.Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexesGemin3 is an essential gene required for larval motor function and pupation in Drosophila.Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring.SMN-assisted assembly of snRNP-specific Sm cores in trypanosomes.Structural basis for specific recognition of pre-snRNA by Gemin5.Biogenesis of spliceosomal small nuclear ribonucleoproteins.A day in the life of the spliceosomeGem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control.UsnRNP biogenesis: mechanisms and regulation.Cajal bodies and their role in plant stress and disease responses.SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila.RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.The right pick: structural basis of snRNA selection by Gemin5.snRNA-specific role of SMN in trypanosome snRNP biogenesis in vivo.Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation.S. cerevisiae Trm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates.Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron.Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation.Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm.
P2860
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P2860
Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Evolution of an RNP assembly s ...... NPs in Drosophila melanogaster
@en
type
label
Evolution of an RNP assembly s ...... NPs in Drosophila melanogaster
@en
prefLabel
Evolution of an RNP assembly s ...... NPs in Drosophila melanogaster
@en
P2093
P2860
P356
P1476
Evolution of an RNP assembly s ...... NPs in Drosophila melanogaster
@en
P2093
Albert Sickmann
Ashwin Chari
Julia Wiesner
Jörg Schultz
Matthias Kroiss
P2860
P304
10045-10050
P356
10.1073/PNAS.0802287105
P407
P50
P577
2008-07-10T00:00:00Z