Targeting protein-protein interactions: lessons from p53/MDM2.
about
Peptides that bind the HIV-1 integrase and modulate its enzymatic activity--kinetic studies and mode of actionSystematic analysis of helical protein interfaces reveals targets for synthetic inhibitorsSurfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsStructural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMXApamin as a novel template for structure-based rational design of potent peptide activators of p53Limitations of Peptide Retro-inverso Isomerization in Molecular MimicryA Left-Handed Solution to Peptide Inhibition of the p53-MDM2 InteractionD-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasmsAn Ultrahigh Affinity d -Peptide Antagonist Of MDM2Motif mediated protein-protein interactions as drug targetsStructural annotation of Mycobacterium tuberculosis proteomeA spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell cultureProbing Difference in Binding Modes of Inhibitors to MDMX by Molecular Dynamics Simulations and Different Free Energy MethodsTherapeutic considerations for Mdm2: not just a one trick ponyModulating protein-protein interactions with small molecules: the importance of binding hotspots.Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?Contemporary strategies for the stabilization of peptides in the alpha-helical conformation.N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53.Small-molecule affinity ligands for protein purification: combined computational enrichment and automated in-line screening of an optically encoded library.PPIMpred: a web server for high-throughput screening of small molecules targeting protein-protein interaction.Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.Novel pyrrolopyrimidine-based α-helix mimetics: cell-permeable inhibitors of protein−protein interactionsBridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability.Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Structural mimicry of the α-helix in aqueous solution with an isoatomic α/β/γ-peptide backbone.Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides.Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.Internalization of p53(14-29) peptide amphiphiles and subsequent endosomal disruption results in SJSA-1 cell death.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsRational design of topographical helix mimics as potent inhibitors of protein-protein interactions.How proteins bind macrocycles.Medicinal chemistry for 2020New Frontiers in DruggabilityDesigner macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Computational studies of difference in binding modes of peptide and non-peptide inhibitors to MDM2/MDMX based on molecular dynamics simulations.γ-AApeptides: Design, Structure, and Applications.Computational Framework for Prediction of Peptide Sequences That May Mediate Multiple Protein Interactions in Cancer-Associated Hub Proteins.Assessment of helical interfaces in protein-protein interactionsNucleation effects in peptide foldamers
P2860
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P2860
Targeting protein-protein interactions: lessons from p53/MDM2.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Targeting protein-protein interactions: lessons from p53/MDM2.
@en
type
label
Targeting protein-protein interactions: lessons from p53/MDM2.
@en
prefLabel
Targeting protein-protein interactions: lessons from p53/MDM2.
@en
P2860
P356
P1433
P1476
Targeting protein-protein interactions: lessons from p53/MDM2.
@en
P2093
Justin K Murray
Samuel H Gellman
P2860
P304
P356
10.1002/BIP.20741
P577
2007-01-01T00:00:00Z