Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.
about
Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapiesInvestigating the dynamic aspects of drug-protein recognition through a combination of MD and NMR analyses: implications for the development of protein-protein interaction inhibitorsCombined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.The thrombospondins.Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2.A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors.Original insights on thrombospondin-1-related antireceptor strategies in cancer.Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach.Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes.Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitorsEndogenous migration modulators as parent compounds for the development of novel cardiovascular and anti-inflammatory drugs.The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis.Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.Thrombospondin-1 Affects Bovine Luteal Function via Transforming Growth Factor-Beta1-Dependent and Independent Actions.DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells.Integration of pro- and anti-angiogenic signals by endothelial cells.N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors.Hydrogen peroxide regulates angiogenesis-related factors in tumor cells.Protein design: from computer models to artificial intelligenceTargeting Difficult Protein-Protein Interactions with Plain and General Computational Approaches
P2860
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P2860
Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@ast
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@en
type
label
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@ast
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@en
prefLabel
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@ast
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@en
P2093
P2860
P50
P356
P1476
Non-peptidic thrombospondin-1 ...... new antiangiogenic compounds.
@en
P2093
Barbara Margosio
Deane F Mosher
Douglas S Annis
Laura Ragona
Lucia Zetta
Marco Neves
Silvia Bonifacio
P2860
P304
P356
10.1074/JBC.M109.085605
P407
P50
P577
2010-01-07T00:00:00Z