Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs.
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Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An OverviewDrug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin CPotential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicinesSchisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathwayMetabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type miceChallenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXRThe sensitivity of cancer cells to pheophorbide a-based photodynamic therapy is enhanced by Nrf2 silencingGenome-wide discovery of drug-dependent human liver regulatory elementsGlucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Improving the oral bioavailability of beneficial polyphenols through designed synergies.Explaining variability in ciclosporin exposure in adult kidney transplant recipients.Garlic extract diallyl sulfide (DAS) activates nuclear receptor CAR to induce the Sult1e1 gene in mouse liver.Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinomaA proposed role for efflux transporters in the pathogenesis of hydrocephalusGenetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR.Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.Cell-based systems to assess nuclear receptor activation and their use in drug development.Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicitiesOrtho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.The nuclear receptor constitutive active/androstane receptor arrests DNA-damaged human hepatocellular carcinoma Huh7 cells at the G2/M phase.Metabolomic screening and identification of the bioactivation pathways of ritonavirUDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP.Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells.The farnesoid X receptor -1G>T polymorphism influences the lipid response to rosuvastatin.Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.Targeted drug delivery to treat pain and cerebral hypoxiaRapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavirBioimaging real-time PXR-dependent mdr1a gene regulation in mdr1a.fLUC reporter mice.Impact of efavirenz on intestinal metabolism and transport: insights from an interaction study with ezetimibe in healthy volunteers.Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymesSteady-state pharmacokinetics of oral voriconazole and its primary metabolite, N-oxide voriconazole, pre- and post-autologous peripheral stem cell transplantation.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Induction of P-glycoprotein by antiretroviral drugs in human brain microvessel endothelial cells.Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liverA new model for studying tissue-specific mdr1a gene expression in vivo by live imaging
P2860
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P2860
Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Nuclear receptors and the regu ...... iability in response to drugs.
@ast
Nuclear receptors and the regu ...... iability in response to drugs.
@en
type
label
Nuclear receptors and the regu ...... iability in response to drugs.
@ast
Nuclear receptors and the regu ...... iability in response to drugs.
@en
prefLabel
Nuclear receptors and the regu ...... iability in response to drugs.
@ast
Nuclear receptors and the regu ...... iability in response to drugs.
@en
P2093
P2860
P356
P1476
Nuclear receptors and the regu ...... iability in response to drugs.
@en
P2093
Bradley L Urquhart
Richard B Kim
Rommel G Tirona
P2860
P304
P356
10.1177/0091270007299930
P577
2007-05-01T00:00:00Z