Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction - Wikidata - wikimedia - TriplyDB

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

http://www.wikidata.org/entity/Q24646162

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Enzyme induction and cytotoxicity in human hepatocytes by chlorpyrifos and N,N-diethyl-m-toluamide (DEET).Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors).Roles of rifampicin in drug-drug interactions: underlying molecular mechanisms involving the nuclear pregnane X receptor.Biology of PXR: role in drug-hormone interactions Nuclear receptors in bone physiology and diseases Marine invertebrate xenobiotic-activated nuclear receptors: their application as sensor elements in high-throughput bioassays for marine bioactive compounds Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRα Conversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands Optimization of stress response through the nuclear receptor-mediated cortisol signalling network Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR Genome-wide discovery of drug-dependent human liver regulatory elements Alterations of chemotherapeutic pharmacokinetic profiles by drug-drug interactions Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts Endocrine-disrupting chemicals and fatty liver disease.Novel functions of PXR in cardiometabolic disease.Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).Functional evolution of the vitamin D and pregnane X receptors.Evolution of pharmacologic specificity in the pregnane X receptor.Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies Hybrid scoring and classification approaches to predict human pregnane X receptor activators Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation.Activation of xenobiotic receptors: driving into the nucleus.

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

http://www.wikidata.org/entity/Q24646162

description

1998 nî lūn-bûn

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1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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1998 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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Proceedings of the National Academy of Sciences of the United States of America

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Identification of a human nucl ...... ng pathway for CYP3A induction

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A Berkenstam

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G Bertilsson

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H Postlind

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J Heidrich

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P2860

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

Activation of the orphan receptor RIP14 by retinoids

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

The nuclear receptor superfamily: the second decade

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1

Identification of a nuclear receptor that is activated by farnesol metabolites

Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols

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