Induction of macrophage colony-stimulating factor-dependent growth and differentiation after introduction of the murine c-fms gene into FDC-P1 cells.
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Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsSuppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signalGab3, a new DOS/Gab family member, facilitates macrophage differentiation.T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationTyrosine 569 in the c-Fms juxtamembrane domain is essential for kinase activity and macrophage colony-stimulating factor-dependent internalizationThe Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.Expression of Mona (monocytic adapter) in myeloid progenitor cells results in increased and prolonged MAP kinase activation upon macrophage colony-stimulating factor stimulation.Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNAScaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinaseThe effect of activating mutations on dimerization, tyrosine phosphorylation and internalization of the macrophage colony stimulating factor receptor.Isolation of new oncogenic forms of the murine c-fms gene.Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cellsAntibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptorMacrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cellsMacrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes.Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell.Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cellsSynergistic suppression: anomalous inhibition of the proliferation of factor-dependent hemopoietic cells by combination of two colony-stimulating factors.FDC-P1 myeloid cells engineered to express fibroblast growth factor receptor 1 proliferate and differentiate in the presence of fibroblast growth factor and heparinThe c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.Colony-stimulating factor-1 receptor utilizes multiple signaling pathways to induce cyclin D2 expression.Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-gamma2 and MAP kinases ERK1 and ERK2.The gene for erythropoietin receptor is expressed in multipotential hematopoietic and embryonal stem cells: evidence for differentiation stage-specific regulation.Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation.The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein.Insulin-like growth factor-1 stimulates proliferation of myeloid FDC-P1 cells overexpressing the human colony-stimulating factor-1 receptor.Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture.Proteomic analysis of macrophage differentiation. p46/52(Shc) Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation.
P2860
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P2860
Induction of macrophage colony-stimulating factor-dependent growth and differentiation after introduction of the murine c-fms gene into FDC-P1 cells.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Induction of macrophage colony ...... c-fms gene into FDC-P1 cells.
@en
type
label
Induction of macrophage colony ...... c-fms gene into FDC-P1 cells.
@en
prefLabel
Induction of macrophage colony ...... c-fms gene into FDC-P1 cells.
@en
P2860
P356
P1476
Induction of macrophage colony ...... c-fms gene into FDC-P1 cells.
@en
P2093
L R Rohrschneider
P2860
P304
P356
10.1128/MCB.9.11.5081
P407
P577
1989-11-01T00:00:00Z