Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.
about
The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxideVanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter.Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II regionCorrection of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)Identification of mutations in the putative ATP-binding domain of the adrenoleukodystrophy genebfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamilyInactivation of the first nucleotide-binding fold of the sulfonylurea receptor, and familial persistent hyperinsulinemic hypoglycemia of infancyCrystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegansCHL1 is a nuclear protein with an essential ATP binding site that exhibits a size-dependent effect on chromosome segregation.A yeast ATP-binding cassette-type protein mediating ATP-dependent bile acid transport.The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae.The yeast a-factor transporter Ste6p, a member of the ABC superfamily, couples ATP hydrolysis to pheromone export.Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopyFunctional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genesCharacterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region.Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.Isolation and sequence analysis of the gene encoding translation elongation factor 3 from Candida albicans.Functional expression of murine multidrug resistance in Xenopus laevis oocytes.Merck Frosst Award Lecture 1998. Molecular dissection of the human multidrug resistance P-glycoprotein.P-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Cytoplasmic dynein light intermediate chain is required for discrete aspects of mitosis in Caenorhabditis elegans.Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding siteKATP channels gated by intracellular nucleotides and phospholipids.Mechanism of coupling of transport to hydrolysis in bacterial ATP-binding cassette transportersIn vitro folding and assembly of the Escherichia coli ATP-binding cassette transporter, BtuCDKinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Genetic aspects of multidrug resistance.CFTR!Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione.The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.The multidrug resistance (mdr1) gene product functions as an ATP channelMutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transportDistinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor
P2860
Q24532117-776DB4DA-5138-47F8-8D04-6D9D8B377F19Q24533561-30A1FC5B-110F-43B3-8513-45114DB82CBDQ24560017-F223DEDE-3DF0-4C47-B1A8-3FA663A13424Q24596052-5F4270BB-57A2-45C8-8230-5BA7534FB3DCQ24628731-19CC4BA6-C959-4AEA-84E8-7BD26355EEB1Q24674299-C4FF4502-0E4C-4F63-899C-73E53154C473Q24675423-FA461158-34C0-4FF6-BF6E-7909E82F171FQ27673547-BB0C71E1-08D4-4491-9BD9-A9B376A25922Q27932199-A6C23B1C-1250-4BE3-B587-2844E0D94B67Q27932862-9CE7529E-948A-4716-952A-4C31B992859DQ27933265-95B9DCF6-4E70-4E1C-91EA-4490A8F13409Q27936552-AEE9643C-E035-4EE5-973F-7E15AB70067BQ28585772-2F18376B-D444-469D-A1E4-6C42969B0F2AQ28589032-5B95C806-D49D-4A7C-AD08-4BC10E748ECFQ30427419-FFB4B9B4-8863-422F-B3D5-99406AFF5D26Q32133639-DAF50759-6B9A-4115-BBBB-55DD50508F1CQ33184830-67546387-3873-48C4-B421-D78E43282923Q33185124-A1986E49-75A8-4C7B-B598-D40408CCD2FDQ33193592-46D98D45-A521-4C97-B4B0-97748742A583Q33226454-AFBCDBBC-301D-41C7-947E-32F0D606D09EQ33642250-C9E1A545-A960-4B78-95BE-FB1FFEE13D75Q33699333-2BC18E3B-79D4-408A-BCD0-987EEF9E1260Q33716375-259EEAE8-95AC-49F7-9DD9-AA4D743601E4Q33800929-559B7BFB-1F05-487A-BB04-AE60EDD11FAFQ33938893-B6A029A3-082F-4D8A-9494-385E3BF06DBFQ33948186-53012E61-0B8B-4612-B517-9A339062EE1FQ34018799-167418DF-A5C4-4395-BC01-5E27D79B3BB7Q34039980-4C6BC6A1-8F7A-462C-8DD6-EEC7A41CE50DQ34530785-34B58B2F-9D0F-41AE-B8DA-677DC163CE9BQ34998163-1D6D157A-5D75-4941-99FF-B726E45B1570Q35181545-C22B8BF9-D5EA-45BA-9D18-6934EE32EA02Q35264223-1CA2A444-DE4B-4634-9385-98D8DF3C1762Q35334619-45AE9A61-2186-45AA-A593-817C4658BD23Q35650714-E2E2C69B-400C-41C6-ABFF-45144AA8142AQ35656224-14A2FC15-B1AB-4EAC-807D-FBA57BC0BBB7Q35843142-8CC03B9B-A011-48B2-8865-A29A933C6EA7Q36045380-794FDB0B-0804-4BAB-8F25-30A1AC6FEA44Q36254821-C51FF9E9-AEFF-42A6-981E-7369B020F0F5Q36309663-5E029828-245A-4862-B079-A86AB50FF0F9Q36436008-DD9A9920-3672-43A2-B822-A7398655AE04
P2860
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Discrete mutations introduced ...... o confer multidrug resistance.
@en
type
label
Discrete mutations introduced ...... o confer multidrug resistance.
@en
prefLabel
Discrete mutations introduced ...... o confer multidrug resistance.
@en
P2093
P2860
P356
P1476
Discrete mutations introduced ...... o confer multidrug resistance.
@en
P2093
P2860
P304
P356
10.1128/MCB.9.12.5289
P407
P577
1989-12-01T00:00:00Z