Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
about
The remarkable transport mechanism of P-glycoprotein: a multidrug transporter.Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex3,3′,4,4′,5-Pentachlorobiphenyl Inhibits Drug Efflux Through P-Glycoprotein in KB-3 Cells Expressing Mutant Human P-GlycoproteinMDR1 causes resistance to the antitumour drug miltefosinePfMDR1: mechanisms of transport modulation by functional polymorphismsSmall molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoproteinMultidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.Mechanisms of multidrug resistance in cancer treatment.Identification and characterization of the binding sites of P-glycoprotein for multidrug resistance-related drugs and modulators.Monitoring PfMDR1 transport in Plasmodium falciparum.Expression of MDR1/P glycoprotein in human sarcomas.Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment.Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoproteinFunctional expression of mouse mdr1 in Escherichia coli.P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity.Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cellsAmino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance.Molecular analysis of the multidrug transporter, P-glycoprotein.Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection.Multidrug efflux pumps: drug binding--gates or cavity?Molecular mechanisms of chemoresistance in osteosarcoma (Review).Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein.Polymorphisms of the TAP 1 and 2 gene may influence clinical outcome of primary dengue viral infection.The genetic basis of resistance to cancer chemotherapy.Photoaffinity labeling of P-glycoprotein in multidrug-resistant cells.Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport.Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents.Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells.Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice.Do adsorbed drugs onto P-glycoprotein influence its efflux capability?Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.Hemolysin transport in Escherichia coli. Point mutants in HlyB compensate for a deletion in the predicted amphiphilic helix region of the HlyA signal.Multidrug Resistance
P2860
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P2860
Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.
description
1990 nî lūn-bûn
@nan
1990 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@ast
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@en
type
label
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@ast
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@en
prefLabel
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@ast
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@en
P2093
P2860
P356
P1476
Molecular basis of preferentia ...... ubstitution in P-glycoprotein.
@en
P2093
I B Roninson
P2860
P304
P356
10.1073/PNAS.87.18.7225
P407
P577
1990-09-01T00:00:00Z