Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
about
Epigenetic regulation of fetal globin gene expression in adult erythroid cellsAnimal models of β-hemoglobinopathies: utility and limitationsHemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Reciprocal regulation of γ-globin expression by exo-miRNAs: Relevance to γ-globin silencing in β-thalassemia major.Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XLKrüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts.Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formationTranscription factors LRF and BCL11A independently repress expression of fetal hemoglobin.The nucleosome remodeling and deacetylase complex in development and disease.Pomalidomide reverses γ-globin silencing through the transcriptional reprogramming of adult hematopoietic progenitorsMinireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicineO-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical DevelopmentCHD4 in the DNA-damage response and cell cycle progression: not so NuRDy nowRecent trends for novel options in experimental biological therapy of β-thalassemia.Recent trends in the gene therapy of β-thalassemia.Hemoglobin genetics: recent contributions of GWAS and gene editing.An Introduction to Erythropoiesis Approaches.In Vitro Erythroid Differentiation and Lentiviral Knockdown in Human CD34+ Cells from Umbilical Cord Blood.Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.A Genetic Variant Ameliorates β-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression.The intrinsic genetic and epigenetic regulator factors as therapeutic targets, and the effect on fetal globin gene expression.Orphan Drugs and Potential Novel Approaches for Therapies of β-Thalassemia: Current Status and Future ExpectationsComparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood
P2860
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P2860
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
@en
type
label
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
@en
prefLabel
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells.
@en
P2093
P2860
P1433
P1476
Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells
@en
P2093
David C Williams
Gordon D Ginder
Maria Amaya
Megha Desai
Sheng Zu Zhu
Shou Zhen Wang
P2860
P304
P356
10.1182/BLOOD-2012-11-466227
P407
P577
2013-02-26T00:00:00Z