Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease.
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Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.Autophagy in lysosomal storage disordersThe pathogenesis of Niemann-Pick type C disease: a role for autophagy?Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filamentsComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseAmyloid-β metabolism in Niemann-Pick C disease models and patients.Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice.Cholesterol-dependent modulation of tau phosphorylation in cultured neurons.Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profilingCholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration.Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts.Multiple pathogenic proteins implicated in neuronopathic Gaucher disease miceAltered transition metal homeostasis in Niemann-Pick disease, type C1.Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 proteinCholesterol and pathological processes in Alzheimer's disease.Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.Niemann-Pick Type C disease and Alzheimer's disease: the APP-endosome connection fattens up.Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice.Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphismsThe many faces of tauPositive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseasesCholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brainSelective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease.Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer.Lipid imbalance in the neurological disorder, Niemann-Pick C disease.Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literatureImpaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C diseaseVariation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain.Cholesterol in Niemann-Pick Type C disease.The role of cholesterol metabolism in Alzheimer's disease.CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY.Early Hippocampal i-LTP and LOX-1 Overexpression Induced by Anoxia: A Potential Role in Neurodegeneration in NPC Mouse Model.Frontal lobe atrophy due to a mutation in the cholesterol binding protein HE1/NPC2.Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathwayIntracellular deposition, microtubule destabilization, and transport failure: an "early" pathogenic cascade leading to synaptic decline.
P2860
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P2860
Paired helical filament tau (PHFtau) in Niemann-Pick type C disease is similar to PHFtau in Alzheimer's disease.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Paired helical filament tau (P ...... PHFtau in Alzheimer's disease.
@en
type
label
Paired helical filament tau (P ...... PHFtau in Alzheimer's disease.
@en
prefLabel
Paired helical filament tau (P ...... PHFtau in Alzheimer's disease.
@en
P2093
P2860
P356
P1476
Paired helical filament tau (P ...... PHFtau in Alzheimer's disease.
@en
P2093
E D Carstea
J Q Trojanowski
M L Schmidt
P G Pentchev
P2860
P2888
P304
P356
10.1007/BF00318566
P577
1995-01-01T00:00:00Z