Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145 - Wikidata - wikimedia - TriplyDB

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145

http://www.wikidata.org/entity/Q36801678

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Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions Molecular controls of the oxygenation and redox reactions of hemoglobin Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin Molecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin.Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin Atherogenesis may involve the prooxidant and proinflammatory effects of ferryl hemoglobin Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo.Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design.Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.Oxidative pathways in the sickle cell and beyond.Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices.Fetal hemoglobin is much less prone to DNA cleavage compared to the adult protein.Redox reactions of hemoglobin: mechanisms of toxicity and control.Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis.Mechanisms involved in hemoglobin-mediated oxidation of lipids in washed fish muscle and inhibitory effects of phospholipase A2.Determination of extinction coefficients of human hemoglobin in various redox states.Mechanisms of Toxicity and Modulation of Hemoglobin-Based Oxygen Carriers (HBOCs).Characterization of Protein-Protein Interactions in Recombinant Hemoglobin Producing Escherichia coli Cells Using Molecularly Imprinted Polymers.Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin.Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage.Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin

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P2860

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145

http://www.wikidata.org/entity/Q36801678

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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type

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Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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prefLabel

Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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Antioxidants & Redox Signaling

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Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145

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Abdu I Alayash

http://www.w3.org/2001/XMLSchema#string

Brandon J Reeder

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Chris E Cooper

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Dimitri A Svistunenko

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Dominik J Schaer

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Gary Silkstone

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Leif Bulow

http://www.w3.org/2001/XMLSchema#string

Michael T Wilson

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Paul W Buehler

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P2860

Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Detection and reactions of the globin radical in haemoglobin.

Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutes.

Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS.

Identification by ENDOR of Trp191 as the free-radical site in cytochrome c peroxidase compound ES.

Redox reactions of hemoglobin and myoglobin: biological and toxicological implications.

Pleiotropic effects of intravascular haemolysis on vascular homeostasis.

Oxygen therapeutics: can we tame haemoglobin?

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2264-2273

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10.1089/ARS.2012.4547.TEST

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17

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2012-08-06T00:00:00Z

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22702311

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3638561

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