Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity.First evidence of the conversion of paracetamol to AM404 in human cerebrospinal fluid.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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Akiko Toda

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Akinobu Yokoyama

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Kanako Miyano

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Masayuki Mogi

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Mayumi Hara

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Mikio Taniguchi

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Seiji Shiraishi

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Shun Muramatsu

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Yasuhito Uezono

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Yoshihiko Kawasaki

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P2860

TRPV1 in brain is involved in acetaminophen-induced antinociception

Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

The anandamide transport inhibitor AM404 activates vanilloid receptors.

Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity.

Paracetamol: past, present, and future.

Paracetamol: new vistas of an old drug.

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

Functional role of high-affinity anandamide transport, as revealed by selective inhibition.

Does therapeutic use of acetaminophen cause acute liver failure?

Paracetamol (Acetaminophen): mechanisms of action.

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Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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P2860

P2860

Metabolism of AM404 From Acetaminophen at Human Therapeutic Dosages in the Rat Brain.

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