Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
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Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible LinkMonomethylarsonous acid inhibited endogenous cholesterol biosynthesis in human skin fibroblasts.Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathyRhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress.Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells.Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1New strategies for the treatment of ovarian cancer.RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells.The effect of statins on cancer cells--review.Exploitation of pleiotropic actions of statins by using tumour-targeted delivery systems.Potentiated suppression of Dickkopf-1 in breast cancer by combined administration of the mevalonate pathway inhibitors zoledronic acid and statins.In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitorsA purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasionMolecular mechanisms linking geranylgeranyl diphosphate synthase to cell survival and proliferation.A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation.Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.Inappropriate movement of Rac1 contributes to glucotoxicity of the islet β-cell.Combined strategy for suppressing breast carcinoma MCF-7 cell lines by loading simvastatin on alpha lipoic acid nanoparticles.An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of simvastatin in cancer cells.
P2860
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P2860
Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@ast
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@en
type
label
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@ast
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@en
prefLabel
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@ast
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@en
P2093
P2860
P356
P1476
Deciphering the signaling netw ...... tion of RhoA and Rac1 GTPases.
@en
P2093
P2860
P356
10.1038/CDDIS.2013.103
P577
2013-04-04T00:00:00Z