Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.
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Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegenerationAdeno Associated Viral Vector Delivered RNAi for Gene Therapy of SOD1 Amyotrophic Lateral SclerosisRetrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and diseaseStem cell transplantation for motor neuron disease: current approaches and future perspectivesCorticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 FunctionHuman neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantationModeling ALS with motor neurons derived from human induced pluripotent stem cellsA perspective on stem cell modeling of amyotrophic lateral sclerosisRecent advances in single-cell MALDI mass spectrometry imaging and potential clinical impactA novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicityAdeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb.Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis.AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS.Evidence for an early innate immune response in the motor cortex of ALS.Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model.Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortexIdentifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity.Visualization of Sensory Neurons and Their Projections in an Upper Motor Neuron Reporter Line.Aberrant neuregulin 1 signaling in amyotrophic lateral sclerosisAnalysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease.Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.Rodent Models of Amyotrophic Lateral SclerosisAbsence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanismsHealthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Marked changes in dendritic structure and spine density precede significant neuronal death in vulnerable cortical pyramidal neuron populations in the SOD1(G93A) mouse model of amyotrophic lateral sclerosisDeciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist.Cross-disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology.Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part II, results and discussionPost-transcriptional regulatory elements and spatiotemporal specification of neocortical stem cells and projection neurons.Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis.Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice.Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS.Resveratrol improves motoneuron function and extends survival in SOD1(G93A) ALS mice.Axonal degeneration as a therapeutic target in the CNS.Molecular logic of neocortical projection neuron specification, development and diversityMoving forward in clinical trials for ALS: motor neurons lead the way please.Amyotrophic lateral sclerosis: a long preclinical period?
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Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G⁹³A transgenic ALS mice.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@ast
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@en
type
label
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@ast
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@en
prefLabel
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@ast
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@en
P2093
P2860
P1476
Corticospinal motor neurons an ...... hSOD1G⁹³A transgenic ALS mice.
@en
P2093
Jeffrey D Macklis
Mine Güzel
P Hande Ozdinler
Susanna Benn
Ted H Yamamoto
P2860
P304
P356
10.1523/JNEUROSCI.4184-10.2011
P407
P577
2011-03-01T00:00:00Z