Detrimental effects of adenosine signaling in sickle cell disease. - Wikidata - wikimedia - TriplyDB

Detrimental effects of adenosine signaling in sickle cell disease.

Detrimental effects of adenosine signaling in sickle cell disease.

http://www.wikidata.org/entity/Q36818005

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Blood cells: an historical account of the roles of purinergic signalling Attenuating myocardial ischemia by targeting A2B adenosine receptors The role of adenosine signaling in sickle cell therapeutics Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites.Beneficial and detrimental role of adenosine signaling in diseases and therapy The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives Adenosine receptors as drug targets--what are the challenges?Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling.Adenosine signaling during acute and chronic disease states Extracellular nucleotide and nucleoside signaling in vascular and blood disease Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation.Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice Early hemorrhage triggers metabolic responses that build up during prolonged shock.Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice Decreased erythrocyte nucleoside transport and hENT1 transporter expression in glucose 6-phosphate dehydrogenase deficiency.Targeting iNKT cells for the treatment of sickle cell disease.Impaired erectile function in CD73-deficient mice with reduced endogenous penile adenosine production Plasma metabolomic profiles enhance precision medicine for volunteers of normal health.Sickling cells, cyclic nucleotides, and protein kinases: the pathophysiology of urogenital disorders in sickle cell anemia.Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway.Three-minute method for amino acid analysis by UHPLC and high-resolution quadrupole orbitrap mass spectrometry.A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.Inflammatory targets of therapy in sickle cell disease.Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.Extracellular adenosine signaling in molecular medicine Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson Adora2b adenosine receptor signaling protects during acute kidney injury via inhibition of neutrophil-dependent TNF-α release CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.Minireview: Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: Early steps to precision medicine Original Research: Diametric effects of hypoxia on pathophysiology of sickle cell disease in a murine model.Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease.Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion Hypoxia signaling during intestinal ischemia and inflammation.Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.

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Detrimental effects of adenosine signaling in sickle cell disease.

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Detrimental effects of adenosine signaling in sickle cell disease.

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Nature Medicine

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Detrimental effects of adenosine signaling in sickle cell disease.

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Danny C Alexander

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Dorothy E Lewis

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Guangxiu Lu

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Harinder S Juneja

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Holger K Eltzschig

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Hong Sun

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Jiaming Wen

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Lijian Tao

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Louvenia Carter-Dawson

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Michael V Milburn

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P2860

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling

Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease.

NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.

A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin.

Sickle cell disease: no longer a single gene disorder.

Understanding the shape of sickled red cells

Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice.

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