Mice expressing activated PI3K rapidly develop advanced colon cancer. - Wikidata - wikimedia - TriplyDB

Mice expressing activated PI3K rapidly develop advanced colon cancer.

Mice expressing activated PI3K rapidly develop advanced colon cancer.

http://www.wikidata.org/entity/Q36821064

about

Mouse models of intestinal cancer Pilot study of sirolimus in patients with PIK3CA mutant/amplified refractory solid cancer.Phospholipid ether analogs for the detection of colorectal tumors.mTOR inhibition elicits a dramatic response in PI3K-dependent colon cancers.Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence.PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors miR-126: A novel regulator in colon cancer Pathology of rodent models of intestinal cancer: progress report and recommendations Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.PIK3CA and APC mutations are synergistic in the development of intestinal cancers.The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.Molecular targets in the discovery and development of novel antimetastatic agents: current progress and future prospects.Rodent intestinal epithelial carcinogenesis: pathology and preclinical models.Serrated neoplasia-role in colorectal carcinogenesis and clinical implications.Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications.Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.New insights into the earliest stages of colorectal tumorigenesis.Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.An immunohistochemical identification key for cell types in adult mouse prostatic and urethral tissue sections.Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis.Apc inactivation, but not obesity, synergizes with Pten deficiency to drive intestinal stem cell-derived tumorigenesis.Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.

P2860

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P2860

Mice expressing activated PI3K rapidly develop advanced colon cancer.

http://www.wikidata.org/entity/Q36821064

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Mice expressing activated PI3K rapidly develop advanced colon cancer.

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type

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Mice expressing activated PI3K rapidly develop advanced colon cancer.

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Mice expressing activated PI3K rapidly develop advanced colon cancer.

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0008-5472.CAN-11-4097

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Cancer Research

P1476

Mice expressing activated PI3K rapidly develop advanced colon cancer.

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P2093

Alyssa A Leystra

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Christopher D Zahm

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Dawn M Albrecht

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Dustin A Deming

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Jamey P Weichert

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Jamie N Hadac

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Jose R Torrealba

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Laura A Nettekoven

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Linda Clipson

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Mary Kay Washington

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P2860

High frequency of mutations of the PIK3CA gene in human cancers

APC mutations occur early during colorectal tumorigenesis

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

Keratin expression in human tissues and neoplasms.

PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.

Reproducibility of tumor volume measurement at microCT colonography in living mice.

Dextran sulfate sodium-induced colitis-associated neoplasia: a promising model for the development of chemopreventive interventions.

Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha.

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2931-2936

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10.1158/0008-5472.CAN-11-4097

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12

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2012-04-23T00:00:00Z

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