The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels
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Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2Epstein-Barr virus nuclear antigen 3C putative repression domain mediates coactivation of the LMP1 promoter with EBNA-2.The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activationThe Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaBA conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of JkappaIntron retention may regulate expression of Epstein-Barr virus nuclear antigen 3 family genesAugmented latent membrane protein 1 expression from Epstein-Barr virus episomes with minimal terminal repeatsRole of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expressionResidues 231 to 280 of the Epstein-Barr virus nuclear protein 2 are not essential for primary B-lymphocyte growth transformation.Interferon regulatory factor 7 is induced by Epstein-Barr virus latent membrane protein 1Mutations in the Epstein-Barr virus latent membrane protein-1 (BNLF-1) gene in spontaneous lymphoblastoid cell lines: effect on in vitro transformation associated parameters and tumorigenicity in SCID and nude miceInterferon regulatory factor 5 represses expression of the Epstein-Barr virus oncoprotein LMP1: braking of the IRF7/LMP1 regulatory circuit.Molecular virology of Epstein-Barr virus.Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.LMP1-induced cell death may contribute to the emergency of its oncogenic property.LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activationEpstein-Barr virus LMP1 modulates the malignant potential of gastric carcinoma cells involving apoptosis.Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA.The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus.The Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor.Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice.Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2.Marked, transient inhibition of expression of the Epstein-Barr virus latent membrane protein gene in Burkitt's lymphoma cell lines by electroporation.Immune regulation in Epstein-Barr virus-associated diseasesTransformation by the oncogenic latent membrane protein correlates with its rapid turnover, membrane localization, and cytoskeletal association.Molecular basis of cytotoxicity of Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) in EBV latency III B cells: LMP1 induces type II ligand-independent autoactivation of CD95/Fas with caspase 8-mediated apoptosis.Transactivation of gene expression by nuclear and cytoplasmic rel proteins.Nuclear factor kappa B-dependent activation of the antiapoptotic bfl-1 gene by the Epstein-Barr virus latent membrane protein 1 and activated CD40 receptor.Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic propertiesThe biological properties of different Epstein-Barr virus strains explain their association with various types of cancersEpstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells.Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA.CD63 Regulates Epstein-Barr Virus LMP1 Exosomal Packaging, Enhancement of Vesicle Production, and Noncanonical NF-κB Signaling.Role of latent membrane protein 1 in chronic active Epstein-Barr virus infection-derived T/NK-cell proliferation.Epstein-Barr virus EBNA-3C is targeted to and regulates expression from the bidirectional LMP-1/2B promoter.The Epstein-Barr virus-encoded LMP-1 oncoprotein negatively affects Tyk2 phosphorylation and interferon signaling in human B cells.Multiple functions within the Epstein-Barr virus EBNA-3A protein.Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression
P2860
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P2860
The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The transforming domain alone ...... when expressed at high levels
@en
type
label
The transforming domain alone ...... when expressed at high levels
@en
prefLabel
The transforming domain alone ...... when expressed at high levels
@en
P2093
P2860
P1433
P1476
The transforming domain alone ...... when expressed at high levels
@en
P2093
V R Baichwal
W Hammerschmidt
P2860
P304
P407
P577
1989-06-01T00:00:00Z