Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
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Structural determinants of cadherin-23 function in hearing and deafnessMutation of the Cyba gene encoding p22phox causes vestibular and immune defects in miceExpression of epithelial calcium transport system in rat cochlea and vestibular labyrinth.Progressive irreversible hearing loss is caused by stria vascularis degeneration in an Slc26a4-insufficient mouse model of large vestibular aqueduct syndromeVestibular dysfunction, altered macular structure and trait localization in A/J inbred mice.Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.Potassium ion movement in the inner ear: insights from genetic disease and mouse modelsGenetics of peripheral vestibular dysfunction: lessons from mutant mouse strains.The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.Integration of human and mouse genetics reveals pendrin function in hearing and deafnessTranscriptional regulation of the pendrin gene.Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium.Vacuolization and alterations of lysosomal membrane proteins in cochlear marginal cells contribute to hearing loss in neuraminidase 1-deficient miceFailure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression.Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin.Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear.Calcium oxalate stone formation in the inner ear as a result of an Slc26a4 mutation.Establishment of a knock-in mouse model with the SLC26A4 c.919-2A>G mutation and characterization of its pathologyMouse models for pendrin-associated loss of cochlear and vestibular functionMechanisms of otoconia and otolith developmentDeletion of the Cl-/HCO3- exchanger pendrin downregulates calcium-absorbing proteins in the kidney and causes calcium wasting.The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal linkA new look at electrolyte transport in the distal tubuleDevelopmental expression of solute carrier family 26A member 4 (SLC26A4/pendrin) during amelogenesis in developing rodent teethThe SLC26 gene family of anion transporters and channels.Functional characterization of pendrin mutations found in the Israeli and Palestinian populations.Pendrin function and regulation in Xenopus oocytesIdentification of allelic variants of pendrin (SLC26A4) with loss and gain of function.Developmental delays consistent with cochlear hypothyroidism contribute to failure to develop hearing in mice lacking Slc26a4/pendrin expression.Mis-trafficking of bicarbonate transporters: implications to human diseases.Molecular and functional characterization of human pendrin and its allelic variants.The role of pendrin in the development of the murine inner ear.Thick airway surface liquid volume and weak mucin expression in pendrin-deficient human airway epithelia.Acidic extracellular microenvironment and cancer.Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15.The ESF meeting on "The proteomics, epigenetics and pharmacogenetics of pendrin".Expression of canonical transient receptor potential channel (TRPC) 1-7 in the mouse inner ear.
P2860
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P2860
Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Lack of pendrin HCO3- transpor ...... tive TRPV5 and TRPV6 channels.
@en
type
label
Lack of pendrin HCO3- transpor ...... tive TRPV5 and TRPV6 channels.
@en
prefLabel
Lack of pendrin HCO3- transpor ...... tive TRPV5 and TRPV6 channels.
@en
P2093
P2860
P1476
Lack of pendrin HCO3- transpor ...... tive TRPV5 and TRPV6 channels.
@en
P2093
Bruce D Schultz
Daniel C Marcus
Donald G Harbidge
Kazuhiro Nakaya
Philine Wangemann
Susan M Wall
P2860
P304
P356
10.1152/AJPRENAL.00432.2006
P577
2007-01-02T00:00:00Z