Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
about
A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrinsStructural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1Structure of an integrin with an αI domain, complement receptor type 4Structure of Collagen Receptor Integrin 1I Domain Carrying the Activating Mutation E317AAn Activating Mutation Reveals a Second Binding Mode of the Integrin α2 I Domain to the GFOGER Motif in CollagensThe Structure of Integrin 1I Domain in Complex with a Collagen-mimetic PeptideAn internal ligand-bound, metastable state of a leukocyte integrin, α X β 2Structural basis of integrin regulation and signalingA small molecule agonist of an integrin, alphaLbeta2.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.Binding between the integrin alphaXbeta2 (CD11c/CD18) and heparinRegulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity stateEarly chordate origin of the vertebrate integrin αI domains.Importance of force linkage in mechanochemistry of adhesion receptors.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrinsRegulation of integrin affinity on cell surfacesThe beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18The regulation of integrin function by divalent cations.The connection between metal ion affinity and ligand affinity in integrin I domainsDynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration.Integrin structures and conformational signalingMutation of a conserved asparagine in the I-like domain promotes constitutively active integrins alphaLbeta2 and alphaIIbbeta3.Identification of integrin beta subunit mutations that alter heterodimer function in situ.Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.Linking integrin conformation to function.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.Neutrophil arrest by LFA-1 activationRedox-relevant aspects of the extracellular matrix and its cellular contacts via integrinsNovel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion.Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding.The integrin alpha L beta 2 hybrid domain serves as a link for the propagation of activation signal from its stalk regions to the I-like domain.Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1.Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands.
P2860
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P2860
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Intersubunit signal transmissi ...... nteraction with a pull spring.
@en
type
label
Intersubunit signal transmissi ...... nteraction with a pull spring.
@en
prefLabel
Intersubunit signal transmissi ...... nteraction with a pull spring.
@en
P2093
P2860
P356
P1476
Intersubunit signal transmissi ...... interaction with a pull spring
@en
P2093
Junichi Takagi
Motomu Shimaoka
Timothy A Springer
P2860
P304
P356
10.1073/PNAS.0307340101
P407
P577
2004-02-20T00:00:00Z