Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.
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Aristolochic acid and the etiology of endemic (Balkan) nephropathyAnalysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acidBalkan endemic nephropathy: an update on its aetiologyBase changes in tumour DNA have the power to reveal the causes and evolution of cancer.Modelling mutational landscapes of human cancers in vitro.TP53 mutations in human cancers: origins, consequences, and clinical useApplications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing.Efficient introduction of specific TP53 mutations into mouse embryonic fibroblasts and embryonic stem cells.Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome.Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases.Contribution of biotransformation enzymes to the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions, difficult answersRegulation of female reproduction by p53 and its family membersTP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts.p53 mutations as fingerprints for aristolochic acid: an environmental carcinogen in endemic (Balkan) nephropathy.Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter.Mutational spectra of human cancer.Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.How the environment shapes cancer genomes.Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing.Nutlin-3a selects for cells harbouring TP53 mutations.The genome as a record of environmental exposureModelling Mutation Spectra of Human Carcinogens Using Experimental Systems.A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutationMetabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts.Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence.Does control of mutant p53 by Mdm2 complicate cancer therapy?Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts.Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes.Validating the concept of mutational signatures with isogenic cell models.
P2860
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P2860
Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Human tumor p53 mutations are ...... arboring a humanized p53 gene.
@en
type
label
Human tumor p53 mutations are ...... arboring a humanized p53 gene.
@en
prefLabel
Human tumor p53 mutations are ...... arboring a humanized p53 gene.
@en
P2093
P2860
P356
P1476
Human tumor p53 mutations are ...... arboring a humanized p53 gene.
@en
P2093
Amanda Hong
Gerald N Wogan
Heinz H Schmeiser
Manfred Hergenhahn
Monica Hollstein
Zhipei Liu
P2860
P304
P356
10.1073/PNAS.0308607101
P407
P577
2004-02-19T00:00:00Z