The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. - Wikidata - wikimedia - TriplyDB

The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.

The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.

http://www.wikidata.org/entity/Q36853414

about

The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.IFN-gamma-inducible Irga6 mediates host resistance against Chlamydia trachomatis via autophagy Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3 Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivo IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes Regulation of macrophage motility by Irgm1 The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?The role of the activated macrophage in clearing Listeria monocytogenes infection p47 GTPases regulate Toxoplasma gondii survival in activated macrophages.Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments Interferon γ-induced GTPase promotes invasion of Listeria monocytogenes into trophoblast giant cells.Analysis of gene expression in ceca of Helicobacter hepaticus-infected A/JCr mice before and after development of typhlitis.Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission The immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashion Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.Pathogen-endoplasmic-reticulum interactions: in through the out door.IRG proteins: key mediators of interferon-regulated host resistance to intracellular pathogens.Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.Balance of Irgm protein activities determines IFN-gamma-induced host defense Toxoplasma gondii and the Immunity-Related GTPase (IRG) resistance system in mice: a review.IFN-inducible p47 GTPases display differential responses to Schistosoma japonicum acute infection.Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancer.Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.A New Role Discovered for IGTP: The Protective Effect of IGTP in ICH-Induced Neuronal Apoptosis.Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides.The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.Intracellular cleavage of glycosylphosphatidylinositol by phospholipase D induces activation of protein kinase Calpha.

P2860

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P2860

The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.

http://www.wikidata.org/entity/Q36853414

description

1997 nî lūn-bûn

@nan

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

1997年论文

@zh

1997年论文

@zh-cn

name

The inducibly expressed GTPase ...... independently of GTP binding.

@en

type

label

The inducibly expressed GTPase ...... independently of GTP binding.

@en

prefLabel

The inducibly expressed GTPase ...... independently of GTP binding.

@en

P1433

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P1476

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P2093

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P2860

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P356

JBC.272.16.10639

P1433

Journal of Biological Chemistry

P1476

The inducibly expressed GTPase ...... independently of GTP binding.

@en

P2093

Hudson E

http://www.w3.org/2001/XMLSchema#string

Pavlakis GN

http://www.w3.org/2001/XMLSchema#string

Pei V

http://www.w3.org/2001/XMLSchema#string

Resau JH

http://www.w3.org/2001/XMLSchema#string

Rulong S

http://www.w3.org/2001/XMLSchema#string

Taylor GA

http://www.w3.org/2001/XMLSchema#string

Vande Woude GF

http://www.w3.org/2001/XMLSchema#string

P2860

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

All ras proteins are polyisoprenylated but only some are palmitoylated

Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro

Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

GTP-binding domain: three consensus sequence elements with distinct spacing.

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group.

Isolation of ras GTP-binding mutants using an in situ colony-binding assay.

Biochemical dissection of AP-1 recruitment onto Golgi membranes.

P304

10639-10645

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P31

scholarly article

P356

10.1074/JBC.272.16.10639

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P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

272

http://www.w3.org/2001/XMLSchema#string

P50

P577

1997-04-01T00:00:00Z

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P5875

14117028

http://www.w3.org/2001/XMLSchema#string

P698

9099712

http://www.w3.org/2001/XMLSchema#string

P921

endoplasmic reticulum