The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.
about
Tandemly arrayed genes in vertebrate genomesDynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27Expression of evolutionarily novel genes in tumorsOrigin of primate orphan genes: a comparative genomics approachEvolutionary diversification of SPANX-N sperm protein gene structure and expressionRapid evolution of cancer/testis genes on the X chromosome.Widespread positive selection in synonymous sites of mammalian genes.Evolution of genetic and genomic features unique to the human lineage.Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation.Relaxed purifying selection and possibly high rate of adaptation in primate lineage-specific genesARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal.A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function.Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families.Positive selection in the evolution of cancer.TAR cloning: insights into gene function, long-range haplotypes and genome structure and evolution.The novelty of human cancer/testis antigen encoding genes in evolutionThe cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion.Sperm-derived SPANX-B is a clinically relevant tumor antigen that is expressed in human tumors and readily recognized by human CD4+ and CD8+ T cells.Sexy gene conversions: locating gene conversions on the X-chromosomeUpregulation of TSPAN12 is associated with the colorectal cancer growth and metastasisTransformation-associated recombination (TAR) cloning for genomics studies and synthetic biology.Codon usage pattern in human SPANX genes.Evolutionary origin and human-specific expansion of a cancer/testis antigen gene family.Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with DMD, FGF13, EGFL6, and Additional Loci at Xp22.2.
P2860
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P2860
The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The SPANX gene family of cance ...... rican great apes and hominids.
@en
type
label
The SPANX gene family of cance ...... rican great apes and hominids.
@en
prefLabel
The SPANX gene family of cance ...... rican great apes and hominids.
@en
P2093
P2860
P356
P1476
The SPANX gene family of cance ...... rican great apes and hominids.
@en
P2093
Greg Solomon
J Carl Barrett
John I Risinger
John Otstot
Michael Mullokandov
N Keith Collins
Natalay Kouprina
Vladimir Larionov
P2860
P304
P356
10.1073/PNAS.0308532100
P407
P577
2004-02-18T00:00:00Z