Simian virus 40 origin DNA-binding domain on large T antigen.
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Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)/cyclinIdentification of a region of simian virus 40 large T antigen required for cell transformationGeometry of the simian virus 40 large tumor antigen-DNA complex as probed by protease digestionRegulation of SV40 DNA replication by phosphorylation of T antigenA deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen.Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity.Production of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen.Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replicationAnalysis of a large-T-antigen variant expressed in simian virus 40-transformed mouse cell line mKS-A.Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124Purification of the simian virus 40 (SV40) T antigen DNA-binding domain and characterization of its interactions with the SV40 origin.Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15.cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigenThe 68-kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitroFunctional characterization of temperature-sensitive mutants of simian virus 40 large T antigenSimian virus 40 (SV40) T-antigen mutations in tumorigenic transformation of SV40-immortalized human uroepithelial cells.The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin meltingThe zinc finger region of simian virus 40 large T antigenAsp-286----Asn-286 in polyomavirus large T antigen relaxes the specificity of binding to the polyomavirus origin.Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation.Thermally inactivated simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitroSpecific mutation of a regulatory site within the ATP-binding region of simian virus 40 large T antigenThe human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites.The T/t common region of simian virus 40 large T antigen contains a distinct transformation-governing sequence.Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: identification of regions restricting transformation by JC virus.The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.Determination of the origin-specific DNA-binding domain of polyomavirus large T antigen.Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replicationGeneration of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen.Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins.Large T antigens of simian virus 40 and polyomavirus efficiently establish primary fibroblasts.Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.Construction and characterization of hybrid polyomavirus genomes.Functional role of BK virus tumor antigens in transformationExpression of polyomavirus virion proteins by a vaccinia virus vector: association of VP1 and VP2 with the nuclear framework.Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication.Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigenRemoval of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA bindingSignal-dependent translocation of simian virus 40 large-T antigen into rat liver nuclei in a cell-free system
P2860
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P2860
Simian virus 40 origin DNA-binding domain on large T antigen.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Simian virus 40 origin DNA-binding domain on large T antigen.
@en
type
label
Simian virus 40 origin DNA-binding domain on large T antigen.
@en
prefLabel
Simian virus 40 origin DNA-binding domain on large T antigen.
@en
P2093
P2860
P1433
P1476
Simian virus 40 origin DNA-binding domain on large T antigen
@en
P2093
P2860
P407
P577
1986-01-01T00:00:00Z