Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
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Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activityActivation of SV40 DNA replication in vitro by cellular protein phosphatase 2AGeometry of the simian virus 40 large tumor antigen-DNA complex as probed by protease digestionRegulation of SV40 DNA replication by phosphorylation of T antigenProduction of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen.Stability and function of JC virus large T antigen and T' proteins are altered by mutation of their phosphorylated threonine 125 residues.Nuclear protein phosphorylation and growth control.Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.The N-terminal side of the origin-binding domain of simian virus 40 large T antigen is involved in A/T untwisting.cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigenStable T-p53 complexes are not required for replication of simian virus 40 in culture or for enhanced phosphorylation of T antigen and p53.Protein phosphatase 2A is required for the initiation of chromosomal DNA replication.Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity.Properties of the DNA-binding domain of the simian virus 40 large T antigen.The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites.Four major sequence elements of simian virus 40 large T antigen coordinate its specific and nonspecific DNA binding.Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene.Mutations that affect phosphorylation of the adenovirus DNA-binding protein alter its ability to enhance its own synthesisModification of fos proteins: phosphorylation of c-fos, but not v-fos, is stimulated by 12-tetradecanoyl-phorbol-13-acetate and serumSimian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences.Expression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells.E2 of cottontail rabbit papillomavirus is a nuclear phosphoprotein translated from an mRNA encoding multiple open reading framesThe two proteins encoded by the cottontail rabbit papillomavirus E6 open reading frame differ with respect to localization and phosphorylation.Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigenRemoval of serine phosphates from simian virus 40 large T antigen increases its ability to stimulate DNA replication in vitro but has no effect on ATPase and DNA bindingBiochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino- and carboxy-terminal domains.Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity.Phosphorylation of simian virus 40 T antigen on Thr 124 selectively promotes double-hexamer formation on subfragments of the viral core origin.The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation.Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector.Phosphorylation of serine residue 89 of human adenovirus E1A proteins is responsible for their characteristic electrophoretic mobility shifts, and its mutation affects biological function.Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids.Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum
P2860
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P2860
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
@en
type
label
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
@en
prefLabel
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
@en
P2093
P2860
P1433
P1476
Phosphorylation downregulates the DNA-binding activity of simian virus 40 T antigen.
@en
P2093
P2860
P304
P407
P577
1986-12-01T00:00:00Z