Airway acidification initiates host defense abnormalities in cystic fibrosis mice. - Wikidata - wikimedia - TriplyDB

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

http://www.wikidata.org/entity/Q36857687

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Epithelial Anion Transport as Modulator of Chemokine Signaling Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and Divergences CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis Marked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel.Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies Engineering Large Animal Species to Model Human Diseases CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes Hyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion.Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease Approaches to Evaluate Lung Inflammation in Translational Research.In Vitro Models to Study Human Lung Development, Disease and Homeostasis.Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase.Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis. What Have We Learned and What Should We Do about It?Genetic medicines for CF: Hype versus reality.Impact of gene editing on the study of cystic fibrosis.Insights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections.Effects of Pseudomonas aeruginosa on CFTR chloride secretion and the host immune response.Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep.A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.Acidosis increases the susceptibility of respiratory epithelial cells to Pseudomonas aeruginosa-induced cytotoxicity.Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis.CK2 is a key regulator of SLC4A2-mediated Cl-/HCO3- exchange in human airway epithelia.Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release.Roadmap for an early gene therapy for cystic fibrosis airway disease.Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.Both Ways at Once: Keeping Small Airways Clean.Use of ferrets for electrophysiologic monitoring of ion transport.Airway surface liquid pH is not acidic in children with cystic fibrosis.Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.Insights from human genetic studies of lung and organ fibrosis.An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.AJRCCM: 100-Year Anniversary. Progress along the Pathway of Discovery Leading to Treatment and Cure of Cystic Fibrosis.

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P2860

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

http://www.wikidata.org/entity/Q36857687

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2016 nî lūn-bûn

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2016 թվականի հունվարին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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name

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

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Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

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Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

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Airway acidification initiates host defense abnormalities in cystic fibrosis mice

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Christine L Wohlford-Lenane

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Kristopher P Heilmann

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Mariah R Leidinger

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Michael J Welsh

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Patrick D Allen

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Philip H Karp

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Sarah E Ernst

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Viral S Shah

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Xiao Xiao Tang

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P2860

Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T

Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

Origins of cystic fibrosis lung disease

Pathophysiology of gene-targeted mouse models for cystic fibrosis

Protein kinase A-independent activation of ERK and H,K-ATPase by cAMP in native kidney cells: role of Epac I

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice.

Nongastric H+,K+-ATPase: cell biologic and functional properties.

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.

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351

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David Meyerholz

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Leah R Reznikov

Lynda S Ostedgaard

Christoph O Randak

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292148217

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26823428

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cystic fibrosis

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4852973

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