Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
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Epithelial Anion Transport as Modulator of Chemokine SignalingAnimal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and DivergencesCFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisMarked increases in mucociliary clearance produced by synergistic secretory agonists or inhibition of the epithelial sodium channel.Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsAcid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapiesEngineering Large Animal Species to Model Human DiseasesCFTR gene transfer with AAV improves early cystic fibrosis pig phenotypesHyperglycaemia and Pseudomonas aeruginosa acidify cystic fibrosis airway surface liquid by elevating epithelial monocarboxylate transporter 2 dependent lactate-H+ secretion.Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung diseaseApproaches to Evaluate Lung Inflammation in Translational Research.In Vitro Models to Study Human Lung Development, Disease and Homeostasis.Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric H,K-ATPase.Early Lung Disease in Infants and Preschool Children with Cystic Fibrosis. What Have We Learned and What Should We Do about It?Genetic medicines for CF: Hype versus reality.Impact of gene editing on the study of cystic fibrosis.Insights into host-pathogen interactions from state-of-the-art animal models of respiratory Pseudomonas aeruginosa infections.Effects of Pseudomonas aeruginosa on CFTR chloride secretion and the host immune response.Year in review 2016: Interstitial lung disease, pulmonary vascular disease, pulmonary function, paediatric lung disease, cystic fibrosis and sleep.A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.Acidosis increases the susceptibility of respiratory epithelial cells to Pseudomonas aeruginosa-induced cytotoxicity.Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis.CK2 is a key regulator of SLC4A2-mediated Cl-/HCO3- exchange in human airway epithelia.Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severityGoblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release.Roadmap for an early gene therapy for cystic fibrosis airway disease.Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.Both Ways at Once: Keeping Small Airways Clean.Use of ferrets for electrophysiologic monitoring of ion transport.Airway surface liquid pH is not acidic in children with cystic fibrosis.Effect of oral glycine on the clinical, spirometric and inflammatory status in subjects with cystic fibrosis: a pilot randomized trial.SLC6A14 Is a Genetic Modifier of Cystic Fibrosis That Regulates Pseudomonas aeruginosa Attachment to Human Bronchial Epithelial Cells.Insights from human genetic studies of lung and organ fibrosis.An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.AJRCCM: 100-Year Anniversary. Progress along the Pathway of Discovery Leading to Treatment and Cure of Cystic Fibrosis.
P2860
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P2860
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
description
2016 nî lūn-bûn
@nan
2016 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
name
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
@en
type
label
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
@en
prefLabel
Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
@en
P2093
P2860
P50
P356
P1433
P1476
Airway acidification initiates host defense abnormalities in cystic fibrosis mice
@en
P2093
Christine L Wohlford-Lenane
Kristopher P Heilmann
Mariah R Leidinger
Michael J Welsh
Patrick D Allen
Philip H Karp
Sarah E Ernst
Viral S Shah
Xiao Xiao Tang
P2860
P304
P356
10.1126/SCIENCE.AAD5589
P407
P50
P577
2016-01-01T00:00:00Z