Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site
about
A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptorsDecreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexiaDifferential agonist sensitivity of glycine receptor alpha2 subunit splice variantsCrystal structure of human glycine receptor-α3 bound to antagonist strychninePoint mutation of glycine receptor alpha 1 subunit in the spasmodic mouse affects agonist responsesMurine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation.Functional reconstitution and characterization of recombinant human alpha 1-glycine receptors.Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.Molecular determinants of proton modulation of glycine receptors.Structure and function of inhibitory glycine receptors.The functional architecture of the acetylcholine nicotinic receptor explored by affinity labelling and site-directed mutagenesis.MDL 27,531 selectively reverses strychnine-induced seizures in miceA cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.The role of glycine in regulated cell death.Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.Selective antagonism of rat inhibitory glycine receptor subunits.Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine.Ivermectin, an unconventional agonist of the glycine receptor chloride channel.Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptors.Structure and biology of inhibitory glycine receptors.In vivo protection against strychnine toxicity in mice by the glycine receptor agonist ivermectin.Actions of 3-[2-phosphonomethyl[1,1-biphenyl]-3-yl]alanine (PMBA) on cloned glycine receptors.Strychnine and taurine modulation of amygdala-associated anxiety-like behavior is 'state' dependent.Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction.Cloning and functional characterization of two glycine receptor alpha-subunits from the perch retina.Bioactive compounds of Shuang-Huang-Lian prescription and an insight into its binding mechanism by β2 -adrenoceptor chromatography coupled with site-directed molecular docking.Cultured oligodendrocyte progenitors derived from cerebral cortex express a glycine receptor which is pharmacologically distinct from the neuronal isoform.Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes.Characterization of the Zebrafish Glycine Receptor Family Reveals Insights Into Glycine Receptor Structure Function and Stoichiometry
P2860
Q21145775-52000E58-A4D8-4C69-A3CD-BA38EE7D00BFQ24568268-EDC25770-A359-4E5B-AEEE-36B5F917FE58Q24671675-BEE84E04-DA34-4790-8F12-C04B8102C6B8Q27702217-75E02EE1-CA5D-4B3C-9D56-3AD23602A262Q28505212-AB3E4C22-CDEF-4F75-9094-196C500E1A47Q30372932-A3D1A060-C478-4D3F-960D-1A7516C7CED5Q30574129-66CFD1E8-A376-4C12-821A-C562775BC4CCQ31807464-DFF06EA7-7D0F-47FC-99E9-3B9D346929D4Q33942239-571C5CC0-6995-470C-B1EB-E328E8591617Q34270612-FBE2C647-EE04-450B-964C-E109420F8C56Q35168987-18FAFBE0-CFA3-4EFB-BCA0-12A6A0734449Q35205566-DA3EE374-207F-4579-8007-DBDB55AD72F2Q35870857-C41CA6FC-422F-4208-860B-11E2C8377A30Q37112929-86F89C0B-B262-4E20-B567-F822521FA80CQ37619407-29C1C8BF-3EC4-4C6A-8DA6-2D1D985A5230Q38804933-93D7E842-F518-4958-9C22-897FEFEF86E3Q40191984-C44C8076-234C-401C-8C78-5DFBD3E5D531Q40612832-4ECE8F67-9CB3-4828-BB82-EB1F4C5AA31BQ40769530-F8D190D4-B271-4445-B144-D3DA31157A72Q40816595-C22F521C-4DE6-4D95-92A3-AF7A992790D8Q41065249-39FD940B-E4D2-4F0E-85F4-96C3C1CCC36BQ41460071-DABD6C10-90CF-4B02-B053-0972B8EEE033Q41900002-81407991-762D-4761-9A04-0693506E7581Q41932131-B88DDBDA-B761-4C9E-AE42-A0400253C181Q42781038-30832649-27F7-426B-B026-1E33CD493481Q43515536-2BB27CCE-DE9F-4184-8C08-67E9427EB744Q44086522-88492B79-A2EE-4E91-B835-CB5D25DE9B0FQ47767951-387D5459-C5A8-4E63-AFCA-A2299D21BFCBQ48345565-80CB6011-68AB-4B1B-987C-D68A66C8136AQ48943899-497A695B-C6D9-4A31-A061-24180A85A945Q57494023-63634765-001A-43CE-8B98-3672E503B860
P2860
Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Antagonism of ligand-gated ion ...... rm the strychnine-binding site
@en
type
label
Antagonism of ligand-gated ion ...... rm the strychnine-binding site
@en
prefLabel
Antagonism of ligand-gated ion ...... rm the strychnine-binding site
@en
P2093
P2860
P356
P1476
Antagonism of ligand-gated ion ...... rm the strychnine-binding site
@en
P2093
Schofield PR
Vandenberg RJ
P2860
P304
P356
10.1073/PNAS.89.5.1765
P407
P577
1992-03-01T00:00:00Z