Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
about
Mechanism of ivermectin facilitation of human P2X4 receptor channelsP2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersCausal Interrogation of Neuronal Networks and Behavior through Virally Transduced Ivermectin Receptors.Glycine receptor mechanism elucidated by electron cryo-microscopy.Crystal structure of a human GABAA receptorPrinciples of activation and permeation in an anion-selective Cys-loop receptorThe antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolismChanging channels in pain and epilepsy: Exploiting ion channel gene therapy for disorders of neuronal hyperexcitabilityA predicted binding site for cholesterol on the GABAA receptorGlycine receptor mouse mutants: model systems for human hyperekplexiaPharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin.Allosteric modulation of glycine receptors.Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivoDorsal unpaired median neurons of locusta migratoria express ivermectin- and fipronil-sensitive glutamate-gated chloride channels.Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice.An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejanaHow do the macrocyclic lactones kill filarial nematode larvae?An improved ivermectin-activated chloride channel receptor for inhibiting electrical activity in defined neuronal populationsMolecular targets and mechanisms for ethanol action in glycine receptorsIvermectin antagonizes ethanol inhibition in purinergic P2X4 receptorsAvermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders.Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway.Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.Salmon lice (Lepeophtheirus salmonis) showing varying emamectin benzoate susceptibilities differ in neuronal acetylcholine receptor and GABA-gated chloride channel mRNA expressionImplication of the purinergic system in alcohol use disorders.Activation and regulation of purinergic P2X receptor channelsFunctional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation.Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytesPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Endectocides for malaria controlTransmembrane voltage potential controls embryonic eye patterning in Xenopus laevis.Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channelIncompatibility between a pair of residues from the pre-M1 linker and Cys-loop blocks surface expression of the glycine receptorMolecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin.Ivermectin reduces alcohol intake and preference in mice.Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors.Involvement of Purinergic P2X4 Receptors in Alcohol Intake of High-Alcohol-Drinking (HAD) RatsFunction of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathwayAllosteric modulation of ATP-gated P2X receptor channels
P2860
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P2860
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
@en
type
label
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
@en
prefLabel
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
@en
P2093
P2860
P356
P1476
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
@en
P2093
P2860
P304
12556-12564
P356
10.1074/JBC.M011264200
P407
P577
2001-01-18T00:00:00Z