Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression
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Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Deletion of the E4 region of the genome produces adenovirus DNA concatemersSecond-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectorsTransduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesisThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseAnalysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Transforming potential of the adenovirus type 5 E4orf3 protein.Tropism and infectivity of duck-derived egg drop syndrome virus in chickensRelocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationThe tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.Adenovirus late gene expression does not require a Rev-like nuclear RNA export pathway.Overexpression of cyclin A inhibits augmentation of recombinant adeno-associated virus transduction by the adenovirus E4orf6 protein.Adenovirus early region 4 stimulates mRNA accumulation via 5' introns.Functional analysis of the adenovirus type 5 DNA-binding protein: site-directed mutants which are defective for adeno-associated virus helper activity.Role of adenovirus type 2 early region 4 in the early-to-late switch during productive infection.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.mRNA export correlates with activation of transcription in human subgroup C adenovirus-infected cellsRegulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Differential activation of cellular DNA damage responses by replication-defective and replication-competent adenovirus mutantsControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityAdenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsHuman adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.The NFIII/OCT-1 binding site stimulates adenovirus DNA replication in vivo and is functionally redundant with adjacent sequencesAdenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transitionActivation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein.Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cellsAggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substratesAdenovirus early region 4 is essential for normal stability of late nuclear RNAsRedundant control of adenovirus late gene expression by early region 4Intranuclear location of the adenovirus type 5 E1B 55-kilodalton protein.A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4.Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection.Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirusGene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides.Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells.Adenovirus early region 1A modulation of interferon antiviral activity
P2860
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P2860
Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Adenoviral early region 4 is r ...... n and for late gene expression
@en
type
label
Adenoviral early region 4 is r ...... n and for late gene expression
@en
prefLabel
Adenoviral early region 4 is r ...... n and for late gene expression
@en
P2860
P1433
P1476
Adenoviral early region 4 is r ...... n and for late gene expression
@en
P2093
D H Weinberg
P2860
P304
P407
P577
1986-03-01T00:00:00Z