Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor
about
Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptorCholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptorFluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor.A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of bindingMolecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.Sensitivity of cholecystokinin receptors to membrane cholesterol content.Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target.Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.
P2860
Q24628602-3020F0B0-09E2-4B17-AB89-A1488E74DFF2Q33838127-8DB09D65-0E04-444D-817D-D7C30A2125D0Q33843640-9611AB7B-5C94-4E3C-AF25-BA8881BF2083Q34073933-EA79532D-F189-43D0-B41B-97B6530047F0Q34785475-D99C5F3B-FB44-466B-BF1A-33CCBE002EAEQ36002904-A3004A97-F051-4009-91A9-AC3C0D8BCEC6Q36329391-483775F6-6991-476B-936D-EB017F0CFD13Q36683781-2F9C247C-3293-4507-AA60-DE50F06D5DB4Q37152806-81E82F22-DEF9-4902-A3A2-3CD5C7FEF8EDQ37175130-2C84D697-8EE7-41DF-8DEE-4D4B51394222Q38828407-BCF73923-794A-4DAF-95A9-028ED180F7F1Q39917756-7BF76278-BA7E-47B3-812F-E10B2708E72A
P2860
Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor
@en
type
label
Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor
@en
prefLabel
Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor
@en
P2093
P2860
P1476
Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor
@en
P2093
Arthur Christopoulos
Laurence J Miller
P2860
P304
P356
10.1016/J.BMCL.2008.06.053
P407
P577
2008-06-20T00:00:00Z