Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor - Wikidata - wikimedia - TriplyDB

Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor

Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor

http://www.wikidata.org/entity/Q36861067

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Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor Cholecystokinin-induced satiety, a key gut servomechanism that is affected by the membrane microenvironment of this receptor Fluorescence polarization screening for allosteric small molecule ligands of the cholecystokinin receptor.A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.Sensitivity of cholecystokinin receptors to membrane cholesterol content.Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and type 2 cholecystokinin receptors.Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.Metabolic Actions of the Type 1 Cholecystokinin Receptor: Its Potential as a Therapeutic Target.Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

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P2860

Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor

http://www.wikidata.org/entity/Q36861067

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor

@en

type

label

Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor

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Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor

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P1433

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P356

J.BMCL.2008.06.053

P1433

Bioorganic & Medicinal Chemistry Letters

P1476

Benzodiazepine ligands can act ...... ype 1 cholecystokinin receptor

@en

P2093

Arthur Christopoulos

http://www.w3.org/2001/XMLSchema#string

Fan Gao

http://www.w3.org/2001/XMLSchema#string

Laurence J Miller

http://www.w3.org/2001/XMLSchema#string

P2860

SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies

Biased probability Monte Carlo conformational searches and electrostatic calculations for peptides and proteins.

Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.

Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor.

Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction

Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling.

Relationship between native and recombinant cholecystokinin receptors: role of differential glycosylation.

The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process.

Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor.

Disulfide bond structure and accessibility of cysteines in the ectodomain of the cholecystokinin receptor: specific mono-reactive receptor constructs examine charge-sensitivity of loop regions.

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4401-4404

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scholarly article

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10.1016/J.BMCL.2008.06.053

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P433

15

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18

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Patrick M. Sexton

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2008-06-20T00:00:00Z

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5230041

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18621527

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P921

Cholecystokinin

P932

2528863

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