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The translational landscape of mTOR signalling steers cancer initiation and metastasis

The translational landscape of mTOR signalling steers cancer initiation and metastasis

http://www.wikidata.org/entity/Q36873513

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Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth Genome-wide annotation and quantitation of translation by ribosome profiling The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments Regulation of global and specific mRNA translation by the mTOR signaling pathway Persistent androgen receptor addiction in castration-resistant prostate cancer Signalling to eIF4E in cancer Next-generation analysis of gene expression regulation--comparing the roles of synthesis and degradation Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation Ribosome profiling: a Hi-Def monitor for protein synthesis at the genome-wide scale Regulation of type I interferon responses Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions mTORC1 signaling activates NRF1 to increase cellular proteasome levels The expanding role of mTOR in cancer cell growth and proliferation mTOR kinase inhibitors as potential cancer therapeutic drugs A ribonucleoprotein complex protects the interleukin-6 mRNA from degradation by distinct herpesviral endonucleases Diverse diseases from a ubiquitous process: the ribosomopathy paradox TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives In vitro models of cancer stem cells and clinical applications Modulation of the Translational Landscape During Herpesvirus Infection mTOR inhibitors in cancer therapy Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1 eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures Translation of 5' leaders is pervasive in genes resistant to eIF2 repression Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies PI3K and cancer: lessons, challenges and opportunities The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase Parallel measurement of dynamic changes in translation rates in single cells.Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype.Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

http://www.wikidata.org/entity/Q36873513

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

The translational landscape of mTOR signalling steers cancer initiation and metastasis

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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The translational landscape of mTOR signalling steers cancer initiation and metastasis

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Andrew C Hsieh

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Annie Sher

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Carly Christensen

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Christian Rommel

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Craig R Stumpf

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Davide Ruggero

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Evan Y Shi

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Katti Jessen

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Kevan M Shokat

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Matthew R Janes

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P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

Generation of a prostate from a single adult stem cell

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55-61

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485

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Jonathan Weissman

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2012-02-22T00:00:00Z

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221863833

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