Molecular hybridization: a useful tool in the design of new drug prototypes.
about
A rapid synthetic route to conformationally restricted [5,5]-bicyclic nucleoside-amino acid conjugates.Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine HybridsDesign, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agentsDiscovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatoninHybrid compounds: from simple combinations to nanomachines.4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation.Identification of a novel selective serotonin reuptake inhibitor by coupling monoamine transporter-based virtual screening and rational molecular hybridizationAntigiardial activity of novel triazolyl-quinolone-based chalcone derivatives: when oxygen makes the difference.Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.Mechanistic Insight of Bivalent Compound 21MO as Potential Neuroprotectant for Alzheimer's DiseaseDesign and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosisNovel heterodimer antibiotics: a review of recent patent literature.Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005 - 2010).Therapeutic potential of new hydrogen sulfide-releasing hybrids.Fragment informatics and computational fragment-based drug design: an overview and update.Recent advances on structural modifications of benzothiazoles and their conjugate systems as potential chemotherapeutics.Advances in the development of hybrid anticancer drugs.New design strategies for antidepressant drugs.Recent advances in the structure-based rational design of TNKSIs.Fragment-based approaches to anti-HIV drug discovery: state of the art and future opportunities.Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profilingMolecular Engineering of Tetracyclic 2,3-Dihydro-1H-benzo[2,3]-benzofuro[4,5-e][1,3]oxazine Derivatives: Evaluation for Potential Anticancer Agents.The potential of combi-molecules with DNA-damaging function as anticancer agents.Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.Synthesis and antitumor activity of novel N-substituted tetrahydro-β-carboline-imidazolium salt derivatives.Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights.Bivalent Compound 17MN Exerts Neuroprotection through Interaction at Multiple Sites in a Cellular Model of Alzheimer's DiseaseEnabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling.Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.Synthesis and antitumor activity of tetrahydrocarbazole hybridized with dithioate derivatives.An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015).Chalcone Derivatives: Promising Starting Points for Drug Design.Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.Synthesis and trypanocidal activity of novel 2,4,5-triaryl-N-hydroxylimidazole derivatives.Chalcone: A Privileged Structure in Medicinal Chemistry.Synthesis of 16 New Hybrids from Tetrahydropyrans Derivatives and Morita-Baylis-Hillman Adducts: In Vitro Screening against Leishmania donovani.Novel Chalcone-Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus.A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase I inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models.Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers.Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents.
P2860
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P2860
Molecular hybridization: a useful tool in the design of new drug prototypes.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Molecular hybridization: a useful tool in the design of new drug prototypes.
@en
type
label
Molecular hybridization: a useful tool in the design of new drug prototypes.
@en
prefLabel
Molecular hybridization: a useful tool in the design of new drug prototypes.
@en
P2093
P1476
Molecular hybridization: a useful tool in the design of new drug prototypes
@en
P2093
Amanda Danuello
Eliezer J Barreiro
Vanderlan da Silva Bolzani
P304
P356
10.2174/092986707781058805
P577
2007-01-01T00:00:00Z