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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNATarget modulation by a kinase inhibitor engineered to induce a tandem blockade of the epidermal growth factor receptor (EGFR) and c-Src: the concept of type III combi-targetingSynthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.A Hybrid Drug Limits Resistance by Evading the Action of the Multiple Antibiotic Resistance Pathway.Coumarin derivatives: an updated patent review (2012-2014).Hybrid curcumin compounds: a new strategy for cancer treatment.An overview of molecular hybrids in drug discovery.Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profilingSynthesis and Antiproliferative Activity of Novel All-Trans-Retinoic Acid-Podophyllotoxin Conjugate towards Human Gastric Cancer Cells.The potential of combi-molecules with DNA-damaging function as anticancer agents.Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.Biological Effect of a Hybrid Anticancer Agent Based on Kinase and Histone Deacetylase Inhibitors on Triple-Negative (MDA-MB231) Breast Cancer Cells.Recent developments with rhodanine as a scaffold for drug discovery.Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells.Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models.Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activityDesign, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
@es
name
Advances in the development of hybrid anticancer drugs.
@en
type
label
Advances in the development of hybrid anticancer drugs.
@en
prefLabel
Advances in the development of hybrid anticancer drugs.
@en
P2860
P1476
Advances in the development of hybrid anticancer drugs.
@en
P2093
Gervais Bérubé
Sébastien Fortin
P2860
P304
P356
10.1517/17460441.2013.798296
P407
P577
2013-05-07T00:00:00Z