Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.
about
Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cellsThe impact of GPCR structures on pharmacology and structure-based drug designBeta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine modelWhat systems can and can't doNon-traditional roles of G protein-coupled receptors in basic cell biologyFragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry.DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells.Agonism and antagonism at the insulin receptor.Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer.Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor.Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cellsInternational Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.Neuropeptide receptor transcript expression levels and magnitude of ionic current responses show cell type-specific differences in a small motor circuit.Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors.Relaxin modulates proinflammatory cytokine secretion from human decidual macrophagesPhenotype pharmacology of lower urinary tract α(1)-adrenoceptors.Annexin A1 interaction with the FPR2/ALX receptor: identification of distinct domains and downstream associated signaling.Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.Identification of alpha 1L-adrenoceptor in mice and its abolition by alpha 1A-adrenoceptor gene knockout.Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathwaysAlpha 1-adrenoceptor pharmacome: alpha 1L-adrenoceptor and alpha 1A-adrenoceptor in the lower urinary tract.Phase-dependent resetting of the adrenal clock by ACTH in vitro.Carbon nanotubes towards medicinal biochips.Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies.Tuning up the right signal: chemical and genetic approaches to study GPCR functions.Structural signatures of DRD4 mutants revealed using molecular dynamics simulations: Implications for drug targeting.Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.Re-evaluation of nicotinic acetylcholine receptors in rat brain by a tissue-segment binding assay.Pharmacologically distinct phenotypes of α1B -adrenoceptors: variation in binding and functional affinities for antagonists.A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer.Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling.Modulation of adenosine A1 and A2A receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine.PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.The Multitarget Ligand 3-Iodothyronamine Modulates β-Adrenergic Receptor 2 Signaling.Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor.The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension.Characterisation of AmphiAmR4, an amphioxus (Branchiostoma floridae) α₂-adrenergic-like G-protein-coupled receptor.β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling.
P2860
Q21093341-BA2C2718-375C-4FD6-BC55-B304A369851EQ24628661-3A80433B-7565-4488-BEF9-38B3D4B37338Q24646260-D7D5CC71-4CFD-40B9-AD24-EE9CFCF8906DQ24654880-49C4D2E1-7B9D-4C58-BD9E-77A0077E5485Q27006799-5CE22032-6E35-43D6-B896-64DCDC97D64BQ31100553-521562A0-534A-419A-BA2B-B17087445C06Q33381275-30FFB1F7-4378-4594-B5A2-8406B3F4706AQ34131036-D4189549-7292-4BF3-AEF8-20049A3F05FDQ34540334-890D8C30-5692-4583-A688-C305457361DDQ34868690-2C4555D7-4E3E-46DF-94ED-52C9EEDAC167Q35046547-05C23648-834B-48E5-BE38-0B52398D293CQ35172234-BD2D78F5-8CF8-4F68-9ED7-9AEE09EF10E4Q35383835-E4F30641-DDAC-42AC-9BC4-C81204B98296Q35547889-A03F51FA-0425-4855-9604-2666AE111CE1Q35618019-16B183DF-6044-4A00-A199-067F290320D4Q35780401-B4E8BC0C-ABF7-4877-9DB3-E16B5406ADC2Q36024814-1CA6FF84-7E72-4509-BB63-33FB9B342C30Q36098069-E4393095-1C80-4BF5-A598-B08F8FB2B212Q36482311-D1E2AB7B-FF72-41E4-878B-05D39F2EC27CQ36573169-7135EC7F-1E62-4A49-AA57-0D8E4BD08745Q37023846-1C107383-4AFB-42EF-9BA4-60E51285E61EQ37175662-3256477F-1033-4324-ABE9-1EB622983789Q37582994-71B5FA12-01B7-4B7F-AAFA-01346A39D09BQ37629373-90B6E439-6BA1-4C61-8034-E239F64DB085Q37668411-DE5E0161-EDB2-4A46-876B-7501971B2452Q37807016-B73DA86C-0DAD-4188-87C1-83B5D16881CCQ38200334-5F3CB627-D284-4FE1-9242-C7123561DF77Q38384318-374AF109-BFFD-409E-B21E-7A56187EE786Q38641723-E6772818-4073-453D-9183-FF08F3CC59B3Q38773768-DE5B64F8-4DF3-418E-86CE-6A43B4B90DEDQ39176672-BBDCC43F-6641-4EFF-9DC2-72881E01300FQ39341462-E6618E3F-1CC2-45DF-BCE3-07E23C0052ECQ39774017-1932554B-8CA5-4CF9-8847-C9BFED52893DQ40006549-55DAFA36-64CA-4D75-949E-8589594F36B3Q40035812-0921E31E-7D24-4680-969C-1E76B6DC0146Q40281437-5DC65567-E2A0-4200-BE4B-D22B740935E5Q42650499-1292660C-0DFF-4D46-BDA3-47EA33291F90Q44343840-6981279B-3220-436B-BBCD-1D62F28E2272Q45232096-52EBC6BD-A227-4076-8E6F-210FDCA6881DQ45306194-6A240E0A-5715-4D8E-930C-05F5C618C777
P2860
Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Multiple GPCR conformations an ...... antagonist affinity estimates.
@en
type
label
Multiple GPCR conformations an ...... antagonist affinity estimates.
@en
prefLabel
Multiple GPCR conformations an ...... antagonist affinity estimates.
@en
P2860
P921
P1476
Multiple GPCR conformations an ...... antagonist affinity estimates
@en
P2093
Jillian G Baker
Stephen J Hill
P2860
P304
P356
10.1016/J.TIPS.2007.06.011
P577
2007-07-13T00:00:00Z