about
The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRsAdenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes.Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactionsIdentification of key residues in transmembrane 4 responsible for the secondary, low-affinity conformation of the human β1-adrenoceptorActivation of phospholipase C by G-protein beta gamma subunits in DDT1MF-2 cells.Reporter-gene systems for the study of G-protein-coupled receptors.Application of BRET to monitor ligand binding to GPCRs.Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor.Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics.G-protein-coupled receptors: past, present and future.Fragment-Based Discovery of Subtype-Selective Adenosine Receptor Ligands from Homology Models.A Perspective on Studying G-Protein-Coupled Receptor Signaling with Resonance Energy Transfer Biosensors in Living Organisms.Histamine H1-agonist potentiation of adenosine-stimulated cyclic AMP accumulation in slices of guinea-pig cerebral cortex: comparison of response and binding parametersMultiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates.Fluorescence- and bioluminescence-based approaches to study GPCR ligand binding.GPCR signaling: understanding the pathway to successful drug discovery.Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment.Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies.Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.Biophysical Detection of Diversity and Bias in GPCR Function.Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig.Cross-talk between different receptor-effector systems in the mammalian CNS.Probing the pharmacology of G protein-coupled receptors with fluorescent ligands.Ligand Residence Time at G-protein-Coupled Receptors-Why We Should Take Our Time To Study It.Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.Structure-Activity Relationships of the Sustained Effects of Adenosine A2A Receptor Agonists Driven by Slow Dissociation Kinetics.Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ)The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cellsAntagonism of central histamine H1 receptors by antipsychotic drugs.Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.Use of a new proximity assay (NanoBRET) to investigate the ligand-binding characteristics of three fluorescent ligands to the human β1-adrenoceptor expressed in HEK-293 cells.The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system.Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation.Transgenic enrichment of cardiomyocytes from human embryonic stem cells.Characterization of isoprenaline- and salmeterol-stimulated interactions between beta2-adrenoceptors and beta-arrestin 2 using beta-galactosidase complementation in C2C12 cells.Interactions between adenosine A1- and histamine H1-receptors.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Stephen J Hill
@nl
Stephen J Hill
@sl
Stephen J. Hill
@en
Stephen J. Hill
@es
ستيفن جيه. هيل
@ar
type
label
Stephen J Hill
@nl
Stephen J Hill
@sl
Stephen J. Hill
@en
Stephen J. Hill
@es
ستيفن جيه. هيل
@ar
prefLabel
Stephen J Hill
@nl
Stephen J Hill
@sl
Stephen J. Hill
@en
Stephen J. Hill
@es
ستيفن جيه. هيل
@ar
P1053
M-6243-2018
P106
P1153
7402765767
P21
P31
P3829
P496
0000-0002-4424-239X