Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
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The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease statesCysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsNeurovascular and neuronal protection by E64d after focal cerebral ischemia in ratsCalpain inhibitor I reduces colon injury caused by dinitrobenzene sulphonic acid in the ratCalpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death.Involvement of calpains in adult neurogenesis: implications for stroke.Neurite consolidation is an active process requiring constant repression of protrusive activity.What animal models have taught us about the treatment of acute stroke and brain protection.Salvaging the ischaemic penumbra: more than just reperfusion?Role of nonfeminizing estrogens in brain protection from cerebral ischemia: an animal model of Alzheimer's disease neuropathology.Reperfusion-induced temporary appearance of therapeutic window in penumbra after 2 h of photothrombotic middle cerebral artery occlusion in rats.Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury.The changing landscape of ischaemic brain injury mechanisms.Neuroprotection with delayed calpain inhibition after transient forebrain ischemia.RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.Magnolol reduces glutamate-induced neuronal excitotoxicity and protects against permanent focal cerebral ischemia up to 4 hoursA pharmacological analysis of the neuroprotective efficacy of the brain- and cell-permeable calpain inhibitor MDL-28170 in the mouse controlled cortical impact traumatic brain injury model.Alzheimer's disease: the pharmacological pathway.Hormesis pervasiveness and its potential implications for pharmaceutical research and development.Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport in an in vivo model of traumatic axonal injury.Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.Clinical trials for cytoprotection in stroke.Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model.All roads lead to disconnection?--Traumatic axonal injury revisited.Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury.Coherent anti-Stokes Raman scattering imaging of myelin degradation reveals a calcium-dependent pathway in lyso-PtdCho-induced demyelination.Endothelin and the neurovascular unit in pediatric traumatic brain injury.DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.Mechanistic role of calpains in postischemic neurodegeneration.Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.Drug therapies for stroke and traumatic brain injury often display U-shaped dose responses: occurrence, mechanisms, and clinical implications.Brain tissue responses to ischemia.Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon.Calpain as a therapeutic target in traumatic brain injury.Lysosomal membrane permeabilization as a key player in brain ischemic cell death: a "lysosomocentric" hypothesis for ischemic brain damage.Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus.The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats.Identification and characterization of PEBP as a calpain substrate.Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis.
P2860
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P2860
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
@en
type
label
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
@en
prefLabel
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
@en
P2093
P356
P1433
P1476
Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats.
@en
P2093
C G Markgraf
D R McCarty
M D Linnik
M P Johnson
N L Velayo
P A Chmielewski
P304
P356
10.1161/01.STR.29.1.152
P407
P577
1998-01-01T00:00:00Z