The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.
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Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicityAromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions.In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitutionCholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses.Fusion-competent state induced by a C-terminal HIV-1 fusion peptide in cholesterol-rich membranes.Binding of anti-membrane-proximal gp41 monoclonal antibodies to CD4-liganded and -unliganded human immunodeficiency virus type 1 and simian immunodeficiency virus virionsNeutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.The Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External RegionClassical swine fever virus p7 protein is a viroporin involved in virulence in swineStructural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10.Large changes in the CRAC segment of gp41 of HIV do not destroy fusion activity if the segment interacts with cholesterol.Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interfaceStructural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.A new paradigm in molecular recognition? Specific antibody binding to membrane-inserted HIV-1 epitopes.Polyreactive antibodies in adaptive immune responses to viruses.Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes.Peripheral Membrane Interactions Boost the Engagement by an Anti-HIV-1 Broadly Neutralizing Antibody.Ablation of the complementarity-determining region H3 apex of the anti-HIV-1 broadly neutralizing antibody 2F5 abrogates neutralizing capacity without affecting core epitope binding.All-or-none versus graded: single-vesicle analysis reveals lipid composition effects on membrane permeabilization.Immunologic Insights on the Membrane Proximal External Region: A Major Human Immunodeficiency Virus Type-1 Vaccine Target.Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions.Confocal microscopy of giant vesicles supports the absence of HIV-1 neutralizing 2F5 antibody reactivity to plasma membrane phospholipids.Lipid modulation of membrane-bound epitope recognition and blocking by HIV-1 neutralizing antibodies.The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects.
P2860
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P2860
The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The broadly neutralizing anti- ...... gnition and blocking than 2F5.
@en
type
label
The broadly neutralizing anti- ...... gnition and blocking than 2F5.
@en
prefLabel
The broadly neutralizing anti- ...... gnition and blocking than 2F5.
@en
P2093
P2860
P356
P1433
P1476
The broadly neutralizing anti- ...... gnition and blocking than 2F5.
@en
P2093
José L Nieva
Maier Lorizate
Nerea Huarte
Rocio Arranz
Rubén Maeso
P2860
P304
P356
10.1128/JVI.00846-08
P407
P577
2008-07-02T00:00:00Z