DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
about
Understanding specific functions of PARP-2: new lessons for cancer therapyPARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.DNA-PK activity is associated with caspase-dependent myogenic differentiation.Common and unique genetic interactions of the poly(ADP-ribose) polymerases PARP1 and PARP2 with DNA double-strand break repair pathways.Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.LINE-1 protein localization and functional dynamics during the cell cycle.Dissection of affinity captured LINE-1 macromolecular complexes.Challenges to DNA replication in hypoxic conditions.Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication.The role of DNA-PK in aging and energy metabolism.Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes.Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
P2860
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P2860
DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
DNA-PKcs and PARP1 Bind to Unr ...... ecruit XRCC1 to Mediate Repair
@en
type
label
DNA-PKcs and PARP1 Bind to Unr ...... ecruit XRCC1 to Mediate Repair
@en
prefLabel
DNA-PKcs and PARP1 Bind to Unr ...... ecruit XRCC1 to Mediate Repair
@en
P2093
P2860
P50
P1433
P1476
DNA-PKcs and PARP1 Bind to Unr ...... ecruit XRCC1 to Mediate Repair
@en
P2093
Annette L Medhurst
Freddie C Hamdy
Huahao Shen
Jessica A Neal
Katheryn Meek
Oliver Mortusewicz
Songmin Ying
Xinming Song
Zhengqiang Bao
Zhihui Chen
P2860
P304
P356
10.1158/0008-5472.CAN-15-0608
P407
P577
2015-11-24T00:00:00Z