FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
about
Maintenance of genome stability by Fanconi anemia proteins.Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity.FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2Analysis of BRCA1/2 mutation spectrum and prevalence in unselected Chinese breast cancer patients by next-generation sequencing.Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.Polθ helicase: drive or reverse.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.Constitutive role of the Fanconi anemia D2 gene in the replication stress response.Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells.RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.Fork Protection and Therapy Resistance in Hereditary Breast Cancer.Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.Processing of DNA Ends in the Maintenance of Genome Stability
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P2860
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on June 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
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FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
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type
label
FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
@en
FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
@nl
prefLabel
FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
@en
FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
@nl
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FANCD2 Maintains Fork Stabilit ...... native End-Joining DNA Repair.
@en
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Alan D D'Andrea
Amie Holmes
Beatrice Rondinelli
Colin O'Leary
David Kozono
Raphael Ceccaldi
Zeina Kais
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P304
P356
10.1016/J.CELREP.2016.05.031
P577
2016-06-01T00:00:00Z