Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
about
Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown miceITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humansEffect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liverCoordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.Membrane transporters in drug developmentProlonged Oral Administration of a Pan-Retinoic Acid Receptor Antagonist Inhibits Spermatogenesis in Mice With a Rapid Recovery and Changes in the Expression of Influx and Efflux Transporters.Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans.Drug uptake systems in liver and kidney: a historic perspectiveMolecular mechanisms of microcystin toxicity in animal cells.Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugsEffect of various diets on the expression of phase-I drug-metabolizing enzymes in livers of miceAssessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses.Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes.Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development.Effects of aging on mRNA profiles for drug-metabolizing enzymes and transporters in livers of male and female miceShort-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice.Renal xenobiotic transporters are differentially expressed in mice following cisplatin treatment.RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice.Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide.Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice.Structure-activity relationship of cyanine tau aggregation inhibitors.Drug interactions at the blood-brain barrier: fact or fantasy?Drug transporters in the human blood-placental barrier.Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models.Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver.Epigenetic regulation of drug processing genes.Inflammation-mediated changes in drug transporter expression/activity: implications for therapeutic drug response.Species differences in drug transporters and implications for translating preclinical findings to humans.Nuclear-receptor-mediated regulation of drug- and bile-acid-transporter proteins in gut and liver.Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics.In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions.Effect of nine diets on xenobiotic transporters in livers of mice.Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver.Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles.Circadian expression profiles of drug-processing genes and transcription factors in mouse liver.Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone.Stickleback embryos use ATP-binding cassette transporters as a buffer against exposure to maternally derived cortisol.
P2860
Q24652340-A88A2D09-04D7-4DB2-81C6-583EAB3FE161Q27022933-4D5AA6A2-F448-490A-A2C0-7A7ACB21E114Q28481289-E33920B5-17EB-4FE1-9A28-03EEBD13BF46Q29347030-91B75566-CB96-4CAC-8061-017872C1CE72Q29616802-B32EF5DC-237F-430C-9128-AB10610324D8Q30353374-0A842D3C-55AB-44C9-BF92-78FF1E26691AQ33436423-0E7DED20-6B4E-4B5E-B55C-780A700328F9Q33641993-3BC31B69-C988-4D6C-A3DE-0D881D3D1865Q33649241-9F11D2EF-1934-4905-A385-18BE9FCEFB27Q33714593-DFD23B9B-4076-47A3-985C-37B8777DF5A5Q33801128-0D4C168E-50FC-4B61-A006-B871CC474D01Q33894107-3A924324-CA37-4818-9F31-701D678F3CD9Q33940094-1D3CE5BE-C397-489C-9610-D18578CCEA23Q34901580-05C28DDC-1B5B-4471-AE24-A9C31E8A27FAQ35234128-592DE58E-45BB-4126-AEC8-15877C8E5B0CQ35969277-DB021C3E-5E55-4615-9B5E-493FE3D00B95Q35996427-D5036C40-DB54-4762-B17C-676AA04B4C05Q36319048-898A0531-3D73-4EA8-93E9-8F0AC347145BQ36944317-6B035F2D-455D-4340-8F7F-5C7BC916ECE0Q36947714-FF82C1A7-ED06-4FF6-8329-BC3E8AAA3660Q37101549-38270155-E166-43F0-9E31-FF4AF32A1805Q37333766-586266F7-766C-46EC-A011-8ABEE87305D1Q37337714-E6337ED9-7CEB-47A7-A517-E88779077763Q37349368-098D2523-39BF-41FE-A3AF-055ABF5E74DEQ37362486-0953DC97-5EAC-4A4F-93AF-173733A98E73Q37395889-817B0935-AC6C-4D30-AA16-0B56F8C9A5B8Q37521097-92C531FB-AEB9-4C0C-997D-57B83717DFEBQ37685403-108C08F4-D1B3-46F6-83AF-F929446D569BQ37865530-2733C8F3-3BFD-4358-9582-4EF47121AD0FQ37964754-E32BAC15-8205-4684-BD25-E7404D0DD01CQ38068912-0B7F32E3-C35A-43DC-9204-84C997E3BCA9Q38074991-D2D8F15F-0091-42E3-B413-F318969FDB65Q38682009-AFB11277-6CF7-4112-A4B0-4B780963B17FQ39730914-A8F7DA62-8712-4A13-ADA3-C6ADCA6A6AE7Q40992681-006EEA4F-A499-43B9-BD64-F018402E5FDEQ42437095-371E6959-AC3A-40FE-AC14-5C507B65C375Q42740587-98C7E81B-0518-43B2-B078-0A7E75B8524AQ43125380-464B5BC5-93BB-4229-ADFB-A95F65A17509Q48469885-0D887487-E14D-43B1-90CC-515AC18829D2Q54839410-BF05223F-F8C8-49EC-A7BA-CCB3C21802E8
P2860
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
@en
type
label
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
@en
prefLabel
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
@en
P2860
P356
P1476
Xenobiotic transporters: ascribing function from gene knockout and mutation studies.
@en
P2093
Curtis D Klaassen
P2860
P304
P356
10.1093/TOXSCI/KFM214
P577
2007-08-13T00:00:00Z